Composition for preventing, relieving or treating colitis, containing complex extracts

Patent metadata

Field	Value
Publication number	US-10195244-B2
Application number	US-201414786754-A
Country	US
Kind code	B2
Filing date	Feb 17, 2014
Priority date	Apr 23, 2013
Publication date	Feb 5, 2019
Grant date	Feb 5, 2019

Abstract

The present invention relates to a novel use of an Anemarrhena asphodeloides Bunge extract, and the like, and a Rhizoma Coptidis extract, and the like, and specifically, provides a composition for preventing, relieving, or treating colitis, including, as active ingredients: one or more selected from the Anemarrhena asphodeloides Bunge extract, a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract, mangiferin, a pharmaceutically acceptable salt of mangiferin, neomangiferin, or a pharmaceutically acceptable salt of neomangiferin; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract.

First claim

What is claimed is:

1. A method for preventing or treating colitis, which comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising a combined extract as active ingredients,
wherein the combined extract consists of a C3 to C8-alcohol-soluble fraction of an Anemarrhena asphodeloides Bunge extract; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract,
wherein the extraction solvent for the Anemarrhena asphodeloides Bunge extract is an alcohol having a carbon number of 1 to 2 or a mixed solvent thereof; and
wherein the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract is obtained by suspending the Anemarrhena asphodeloides Bunge extract by adding water thereto followed by fractionation after adding an alcohol having a carbon number of 3 to 8 thereto.

2. The method of claim 1 , wherein the weight ratio between the C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract; and the one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract is in the range of from 10:1 to 1:10.

3. The method of claim 1 , wherein the colitis is an inflammatory bowel disease or an irritable bowel syndrome.

4. The method of claim 1 , wherein the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract is a butanol-soluble fraction of the Anemarrhena asphodeloides Bunge extract.

5. The method of claim 1 , wherein the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract comprises mangiferin or neomangiferin.

6. The method of claim 1 , wherein the Rhizoma Coptidis is Coptis chinensis.

7. The method of claim 1 , wherein the extraction solvent of the Rhizoma Coptidis extract is water, an alcohol having a carbon number of 1 to 2, or a mixed solvent thereof.

8. The method of claim 7 , wherein the alcohol-soluble fraction of the Rhizoma Coptidis extract is obtained by suspending the Rhizoma Coptidis extract by adding water thereto followed by fractionation after adding an alcohol having a carbon number of 3 to 8 thereto.

9. The method of claim 8 , wherein the alcohol-soluble fraction of the Rhizoma Coptidis extract is a butanol-soluble fraction of the Rhizoma Coptidis extract.

10. The method of claim 1 , wherein the Rhizoma Coptidis extract or the alcohol-soluble fraction of the Rhizoma Coptidis extract comprises berberine.

11. The method of claim 1 , wherein the active ingredients are a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and a Rhizoma Coptidis extract, and the weight ratio between the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and the Rhizoma Coptidis extract is in the range of from 1:1 to 5:1.

12. The method of claim 1 , wherein the active ingredients are a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract, and the weight ratio between the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and the alcohol-soluble fraction of the Rhizoma Coptidis extract is in the range of from 1:1 to 5:1.

13. A method for preventing or improving colitis, which comprises administering to a subject in need thereof an effective amount of a food composition comprising a combined extract as active ingredients,
wherein the combined extract consists of a C3 to C8-alcohol-soluble fraction of an Anemarrhena asphodeloides Bunge extract; and one or more selected from a Rhizoma Coptidis extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract,
wherein the extraction solvent for the Anemarrhena asphodeloides Bunge extract is an alcohol having a carbon number of 1 to 2 or a mixed solvent thereof; and
wherein the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract is obtained by suspending the Anemarrhena asphodeloides Bunge extract by adding water thereto followed by fractionation after adding an alcohol having a carbon number of 3 to 8 thereto.

14. The method of claim 13 , wherein the Rhizoma Coptidis is Coptis chinensis.

15. The method of claim 13 , wherein the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract is a butanol-soluble fraction of the Anemarrhena asphodeloides Bunge extract, and the alcohol-soluble fraction of the Rhizoma Coptidis extract is a butanol-soluble fraction of the Rhizoma Coptidis extract.

16. The method of claim 13 , wherein the active ingredients are an a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and a Rhizoma Coptidis extract, and the weight ratio between the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and the Rhizoma Coptidis extract is in the range of from 1:1 to 5:1.

17. The method of claim 13 , wherein the active ingredients are a C3 to C8-alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and a C3 to C8-alcohol-soluble fraction of the Rhizoma Coptidis extract, and the weight ratio between the alcohol-soluble fraction of the Anemarrhena asphodeloides Bunge extract and the alcohol-soluble fraction of the Rhizoma Coptidis extract is in the range of from 1:1 to 5:1.

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Kim Dong Hyun
• Han Myung Joo

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A23L23/00

  Soups; Sauces (soya sauce A23L27/50; salad dressings, mayonnaise or ketchup A23L27/60); Preparation or treatment thereof · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A23L2/02

  containing fruit or vegetable juices · CPC title