Methods for therapeutic renal denervation

Patent metadata

Field	Value
Publication number	US-10194983-B2
Application number	US-201715837488-A
Country	US
Kind code	B2
Filing date	Dec 11, 2017
Priority date	Apr 8, 2002
Publication date	Feb 5, 2019
Grant date	Feb 5, 2019

Abstract

Methods for therapeutic renal denervation are disclosed herein. One aspect of the present application, for example, is directed to methods that block, reduce and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry several therapeutic benefits across many disease states.

First claim

We claim:

1. A method, comprising:
positioning an electrode within a renal artery of a hypertensive human patient and proximate to renal nerves along the renal artery;
ablating the renal nerves via electrical energy from the electrode at a plurality of locations along a wall of the renal artery; and
removing the electrode from the patient after ablating the renal nerves,
wherein the patient achieves a decrease in systolic blood pressure of at least 10 mm Hg by three months as a result of ablating the renal nerves.

2. The method of claim 1 wherein the patient achieves a decrease in diastolic blood pressure of at least 5 mm Hg by three months after ablation of the renal nerves.

3. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 20 mm Hg by six months after ablation of the renal nerves.

4. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 25 mm Hg by six months after ablation of the renal nerves.

5. The method of claim 1 wherein the patient achieves a decrease in diastolic blood pressure of at least 10 mm Hg by six months after ablation of the renal nerves.

6. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 20 mm Hg by twelve months after ablation of the renal nerves.

7. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 20 mm Hg by eighteen months after ablation of the renal nerves.

8. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 25 mm Hg by eighteen months after ablation of the renal nerves.

9. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 25 mm Hg by twenty four months after ablation of the renal nerves.

10. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 30 mm Hg by twenty four months after ablation of the renal nerves.

11. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure of at least 30 mm Hg by twenty four months after ablation of the renal nerves.

12. The method of claim 1 wherein the patient achieves a decrease in systolic blood pressure at twenty four months after ablation of the renal nerves greater than the observed decrease in systolic blood pressure at twelve months after modulation.

13. The method of claim 1 wherein the patient achieves a decrease in diastolic blood pressure at twenty four months after ablation of the renal nerves greater than the observed decrease in diastolic blood pressure at twelve months after modulation.

14. The method of claim 1 wherein the patient has a baseline blood pressure before treatment of at least about 160 mm Hg.

15. The method of claim 1 wherein the electrode is one of a plurality of bipolar electrodes carried by an expandable balloon, and wherein:
positioning an electrode within a renal artery of a hypertensive human patient comprises positioning the balloon at a distal portion of the renal artery and transforming the balloon from a low-profile delivery configuration into a deployed configuration such that the bipolar electrodes carried by the balloon are positioned in contact with treatment locations along the wall of the renal artery; and
ablating the renal nerves comprises delivering electrical energy via the bipolar electrodes to the renal nerves along the renal artery.

16. The method of claim 1 wherein:
the electrode is one of a plurality of electrodes arranged along an elongated member, and further wherein the elongated member is transformable between (a) a low-profile delivery arrangement for intravascularly passage to a target site within the renal artery and (b) a deployed arrangement in which the elongated member assumes a generally helical shape and is configured to contact the wall of the renal artery;
positioning an electrode within a renal artery of a hypertensive human patient comprises transforming the elongated member from the delivery arrangement into the deployed arrangement such that the elongated member assumes the generally helical shape and the plurality of electrodes carried thereon are positioned in contact with treatment locations arranged in a helical pattern along the wall of the renal artery; and
ablating the renal nerves comprises delivering electrical energy via the plurality of electrodes to the renal nerves along the renal artery.

Assignees

• Medtronic Ardian Luxembourg

Inventors

• Barman Neil
• Levin Howard
• Sobotka Paul
• Gelfand Mark

Classifications

• A61B18/082

  Probes or electrodes therefor · CPC title

• A61B2018/00791

  Temperature · CPC title

• A61B2018/00702

  Power or energy · CPC title

• A61B2018/0212

  using an instrument inserted into a body lumen, e.g. catheter · CPC title

• A61B2018/00434

  Neural system · CPC title