Implantation devices including hydrogel filaments

Patent metadata

Field	Value
Publication number	US-10194915-B2
Application number	US-201615272305-A
Country	US
Kind code	B2
Filing date	Sep 21, 2016
Priority date	Dec 21, 2007
Publication date	Feb 5, 2019
Grant date	Feb 5, 2019

Abstract

Described are devices for implantation comprising a hydrogel filament wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer, an ethylenically unsaturated monomer, and a visualization agent. Methods of making and using these devices are also described.

First claim

We claim:

1. A device for implantation comprising:
a hydrogel filament attached to a coupler wherein the coupler is attached to a pusher,
wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer; an ethylenically unsaturated monomer; and visualization agent having a structure of 2,4,6-triiodophenyl penta-4-enoate,
wherein said device contains no support members.

2. The device of claim 1 , wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole.

3. The device of claim 1 , wherein said macromer comprises polyethylene glycol, propylene glycol, poly(tetramethylene oxide), poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) di methacrylate, derivatives thereof, or combinations thereof.

4. The device of claim 1 , wherein said macromer and said monomer are crosslinked with N,N,N′,N′-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof.

5. The device of claim 1 , wherein said hydrogel is substantially free of acrylamide.

6. The device of claim 1 , wherein said hydrogel is substantially non-bioresorbable.

7. The device of claim 1 , wherein said visualization agent is at a concentration of about 40% w/w to about 80% w/w of a prepolymer solution used to form the hydrogel filament.

8. A device for implantation comprising:
an introducer loaded with a hydrogel filament, wherein the introducer attaches to a catheter or microcatheter,
wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer; an ethylenically unsaturated monomer; and visualization agent having a structure of 2,4,6-triiodophenyl penta-4-enoate,
wherein said device contains no support members.

9. The device of claim 8 , wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole.

10. The device of claim 8 , wherein said macromer comprises polyethylene glycol, propylene glycol, poly(tetramethylene oxide), poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) di methacrylate, derivatives thereof, or combinations thereof.

11. The device of claim 8 , wherein said macromer and said monomer are crosslinked with N,N,N′,N′-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof.

12. The device of claim 8 , wherein said hydrogel is substantially free of acrylamide.

13. The device of claim 8 , wherein said hydrogel is substantially non-bioresorbable.

14. The device of claim 8 , wherein said visualization agent is at a concentration of about 40% w/w to about 80% w/w of a prepolymer solution used to form the hydrogel filament.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Constant Michael J
• Keeley Edward Michael
• Tran Terrance T

Classifications

• A61B2017/00004

  (bio)absorbable, (bio)resorbable or resorptive · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61K49/0404

  containing barium sulfate · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title