Device for manufacturing cell-derived vesicles and manufacturing method using same
US-2024200008-A1 · Jun 20, 2024 · US
US10190089B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10190089-B2 |
| Application number | US-201715827574-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 30, 2017 |
| Priority date | Jul 9, 2007 |
| Publication date | Jan 29, 2019 |
| Grant date | Jan 29, 2019 |
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A modular automated system for sample processing and/or detection of microorganisms is provided. The modular system includes modules that perform at least one function in the process of detecting microorganisms in a culture device, such as collection of multiple samples, sample loading, sample preparation, sample incubation, and detection of microorganisms in samples. An exemplary embodiment of a modular sample processing and/or detection system can include an automated loading module, a liquid processing module, modular incubator, a second automated loading module, a reader module, and a collector.
Opening claim text (preview).
What is claimed is: 1. A method for detecting a microorganism, the method comprising (i) inserting a culture device into a modular system, the modular system comprising a plurality of freestanding modules, the plurality of freestanding modules including: a freestanding first module configured to hold a stomacher bag comprising a liquid sample; a freestanding second module configured to transfer the liquid sample to the culture device; and a freestanding third module comprising a housing and a detector, wherein a first slot, a second slot, and a third slot are formed in the housing of the freestanding third module, the freestanding third module configured to receive the culture device through the first slot; interlocking features to align two or more freestanding modules of the plurality of freestanding modules; and a data processor, wherein the data processor is programmed to: receive at least one user-established preset criterion that defines a quantity of microorganism colonies; receive colony count information from the detector; compare the colony count information to the at least one preset criterion to determine whether one or more conditions exist in the culture device; configure the freestanding third module to eject the culture device through the second slot when the one or more conditions exist in the culture device; and configure the freestanding third module to eject the culture device through the third slot when the one or more conditions do not exist in the culture device; (ii) analyzing the culture device for colony count information with the detector; and (iii) provide the colony count information from the detector to the data processor. 2. The method of claim 1 , wherein the modular system comprises a sample reservoir module and holding a sample reservoir thereon. 3. The method of claim 1 , wherein the modular system comprises a liquid processing module and the method further comprises the step of transferring a liquid sample to the liquid processing module. 4. The method of claim 1 , wherein the at least one preset criterion includes a second preset criterion that includes the microorganism type. 5. The method of claim 1 , wherein the at least one preset criterion includes a second preset criterion that includes the plate type. 6. The method of claim 1 , wherein the at least one preset criterion includes a second preset criterion that includes the sample type. 7. The method of claim 1 , wherein the modular system further comprises a collator, and further comprising the step of that operating the collector cooperatively with the processor to collate the culture devices according to the at least one preset criterion. 8. The method of claim 1 , wherein: each respective freestanding module of the plurality of freestanding modules comprising a respective housing, and for each respective freestanding module of the plurality of freestanding modules, the housing of the respective freestanding module defines one or more of the interlocking features, the interlocking features of the respective freestanding module aligning the respective freestanding module with one or more freestanding modules of the plurality of freestanding modules, each of the one or more interlocking features of the respective freestanding module being at least one of a projection or an indentation, wherein the interlocking features defined by the housings of the freestanding modules of the plurality of freestanding blocks are shaped such that the plurality of freestanding modules are capable of being aligned in a predetermined sequential order for use but prevent configuration of the plurality of freestanding modules in an order that prevents or inhibits sample processing or detection.
Measuring or testing with condition measuring or sensing means, e.g. colony counters · CPC title
Multiple separable units; Modules · CPC title
Automatic or computerized control (automatic analysis G01N35/00) · CPC title
Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor {(C12Q1/6897 takes precedence)} · CPC title
of cellular or enzymatic activity or functionality, e.g. cell viability · CPC title
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