Apparatus and methods for drug delivery using multiple reservoirs

Patent metadata

Field	Value
Publication number	US-10188550-B2
Application number	US-201414894161-A
Country	US
Kind code	B2
Filing date	May 30, 2014
Priority date	Jun 3, 2013
Publication date	Jan 29, 2019
Grant date	Jan 29, 2019

Abstract

A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

First claim

What is claimed:

1. An apparatus, comprising:
a housing;
a cartridge assembly, at least a portion of the cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, the second movable member including a seal member configured to form a fluidic seal with an inner surface of the first movable member, the first movable member defining an inner volume bounded by the seal member and the inner surface of the first movable member, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position relative to the first movable member;
a first reservoir disposed within the inner volume such that the first reservoir is disposed in a distal position relative to the second movable member, the first reservoir containing a drug when the second movable member is in its first position relative to the first movable member, the first reservoir not being in fluid communication with the inner volume when the second movable member is in its first position, the first reservoir being placed in fluid communication with the inner volume when the second movable member is in its second position relative to the first movable member, the first movable member including a valve member configured to be transitioned from a closed configuration when the second movable member is in its first position relative to the first movable member to an open configuration (1) when the second movable member is moved toward its second position relative to the first movable member, and (2) in response to an increase in pressure within the first reservoir by distal movement of the second movable member from its first position towards its second position, the valve member further configured to be transitioned from the open configuration to the closed configuration after the second movable member is moved towards its second position relative to the first movable member; and
a second reservoir at least partially defined by the housing, a portion of the first movable member being movably disposed in the second reservoir, the second reservoir being fluidically isolated from the inner volume when the second movable member is in its first position relative to the first movable member and the valve member is in its closed configuration, the second reservoir being placed in fluid communication with the inner volume when the second movable member is moved toward its second position relative to the first movable member to receive a volume of the drug from the first reservoir and the valve member is in its open configuration, the first movable member and the second movable member collectively configured to be moved distally from a first position relative to the housing to a second position relative to the housing to expel the volume of the drug from the second reservoir.

2. The apparatus of claim 1 , wherein the housing has a proximal end portion and a distal end portion, the proximal end portion defining an opening to receive at least a portion of the cartridge assembly, the distal end portion being physically and fluidically coupled to a puncture member, the puncture member being in fluid communication with the second reservoir.

3. The apparatus of claim 2 , wherein the puncture member is configured to puncture ocular tissue of a patient.

4. The apparatus of claim 1 , wherein the second reservoir includes a volumetric indicator.

5. The apparatus of claim 1 , wherein the first reservoir is a deformable reservoir, the first reservoir including a portion configured to break open when the second movable member is moved toward its second position relative to the first movable member.

6. The apparatus of claim 1 , wherein the first reservoir is a deformable reservoir, the first reservoir configured to be transitioned from a substantially undeformed configuration, in which the first reservoir contains the drug, to a deformed configuration, in which the volume of the drug is disposed substantially outside of the first reservoir.

7. The apparatus of claim 6 , wherein the first movable member includes an inner surface that forms a shoulder configured to be in contact with the first reservoir, the shoulder configured to transition the first reservoir, at a point of the contact, from the substantially undeformed configuration to the deformed configuration in response to the movement of the second movable member from its first position to its second position relative to the first movable member.

8. The apparatus of claim 1 , further comprising:
a safety tab movably coupled to the housing, the safety tab configured to be placed in contact with first movable member to selectively limit a movement of the first movable member relative to the housing.

9. The apparatus of claim 1 , wherein the valve member is a check valve, a ball valve, a diaphragm valve, a stop valve, or a duckbill valve.

10. The apparatus of claim 1 , wherein the valve member is a one way valve.

11. The apparatus of claim 1 , further comprising:
an actuator configured to transition the valve between its closed configuration and its open configuration, the actuator including at least one of a toggle, a switch, a button, a slide, or a knob.

12. The apparatus of claim 1 , wherein the valve member is a first valve member, the housing including a second valve member disposed in the second reservoir.

13. The apparatus of claim 1 , wherein the inner volume is a first inner volume and the housing defines a second inner volume and is configured to receive a portion of a safety tab such that the safety tab extends from a first radial side of the housing to a second radial side of the housing, traversing the second inner volume, the first radial side being located opposite the second radial side, and engages the first movable member to selectively limit movement of the first movable member relative to the housing when the safety tab is engaged with the first movable member and the housing.

14. The apparatus of claim 1 , wherein the valve member is a first valve member, the second reservoir further including a second valve member, the second valve member configured to be transitioned from a closed configuration to an open configuration in response to the first movable member being moved distally from the first position relative to the housing to the second position relative to the housing.

15. The apparatus of claim 1 , wherein the housing has a proximal end portion and a distal end portion, the proximal end portion defining an opening to receive at least a portion of the cartridge assembly, the distal end portion being physically and fluidically coupled to a puncture member, the puncture member configured to be in fluid communication with the second reservoir in response to an increase in pressure in the second reservoir.

16. An apparatus, comprising:
a housing having a distal end portion, the distal end portion defining a substantially rigid reservoir physically and fluidically coupled to a puncture member, the puncture member configured to puncture ocular tissue of a patient; and
a cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, at least a portion of the first movable member configured to be disposed in the substantially rigid reservoir, the first movable member having a shoulder and defining an inner volume, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position, the cartridge

Assignees

• Clearside Biomedical Inc

Inventors

• Andino Rafael Victor
• Patel Samirkumar R
• Zarnitsyn Vladimir
• Brooks Christopher John

Classifications

• A61F9/0017 Primary

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61M5/284

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61M5/19

  having more than one chamber {, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly (surgical glue applicators A61B17/00491)} · CPC title

• A61M2005/31598

  having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed · CPC title

• A61J1/2093

  Containers having several compartments for products to be mixed · CPC title