Activation of bioluminescence by structural complementation
US-9869670-B2 · Jan 16, 2018 · US
Activation of bioluminescence by structural complementation
US10184936B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10184936-B2 |
| Application number | US-201815899219-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 19, 2018 |
| Priority date | Mar 15, 2013 |
| Publication date | Jan 22, 2019 |
| Grant date | Jan 22, 2019 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated composition comprising: (a) a polypeptide comprising SEQ ID NO: 1270; (b) a first peptide comprising SEQ ID NO: 2587; and (c) a second peptide comprising SEQ ID NO: 374. 2. The isolated composition of claim 1 , wherein one or more of the polypeptide, first peptide, and second peptide are conjugated to a molecular entity. 3. The isolate composition of claim 2 , wherein the molecular entity is selected from the group consisting of a small molecule, antibody, antibody fragment, peptide, carbohydrate, or protein.
Assignees
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Classifications
- C12N9/0069Primary
acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13) · CPC title
with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates) · CPC title
- G01N33/533Primary
with fluorescent label · CPC title
with steric inhibition or signal modification, e.g. fluorescent quenching · CPC title
- C07K7/08Primary
having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title
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- What does patent US10184936B2 cover?
- Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
- Who is the assignee on this patent?
- Promega Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0069. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).