Aza-pyridone compounds and uses thereof
US-2016264581-A1 · Sep 15, 2016 · US
Method of preparing AZA-pyridone compounds
US10183945B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10183945-B2 |
| Application number | US-201715455780-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 10, 2017 |
| Priority date | Mar 10, 2016 |
| Publication date | Jan 22, 2019 |
| Grant date | Jan 22, 2019 |
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Abstract
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Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of preparing a compound of Formula (DD) comprising the step of reacting a compound of Formula (CC) with a hydride source in the presence of a carbonyl reductase to form a compound of Formula (DD), wherein the carbonyl reductase is selected from CRED-121, CRED-41, CRED-52, CRED-155, and CRED-163. 2. The method of claim 1 , wherein the carbonyl reductase is selected from CRED-121 and CRED-41. 3. The method of claim 2 , wherein the carbonyl reductase is CRED-121. 4. The method of claim 2 , wherein the carbonyl reductase is CRED-41. 5. The method of claim 1 , wherein the hydride source is (i) a cofactor selected from NAD and NADP, (ii) a reducing sugar, and (iii) a dehydrogenase that dehydrogenates the reducing sugar. 6. The method of claim 5 , wherein the reducing sugar is glucose and the dehydrogenase is glucose dehydrogenase. 7. The method of claim 5 , wherein the cofactor is NADP. 8. The method of claim 5 , wherein the cofactor is NAD.
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Classifications
aromatic · CPC title
Carbonyl reductase (NADPH) (1.1.1.184) · CPC title
- C07D487/04Primary
Ortho-condensed systems · CPC title
Glucose dehydrogenase (acceptor) (1.1.99.10) · CPC title
Hydrosilylation reactions · CPC title
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Frequently asked questions
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- What does patent US10183945B2 cover?
- Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection.
- Who is the assignee on this patent?
- Alios Biopharma Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 22 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).