Assembly, instrument for performing a temperature-dependent reaction and method for performing a temperature-dependent reaction in an assembly

Patent metadata

Field	Value
Publication number	US-10183296-B2
Application number	US-201715693009-A
Country	US
Kind code	B2
Filing date	Aug 31, 2017
Priority date	Sep 1, 2016
Publication date	Jan 22, 2019
Grant date	Jan 22, 2019

Abstract

An assembly comprising a sample block, a heat sink and at least one electrodeposited thermoelectric element is disclosed. Further, an instrument and a method for performing a temperature-dependent reaction are disclosed.

First claim

The invention claimed is:

1. An assembly comprising a sample block, a heat sink and at least one electrodeposited thermoelectric element, wherein the sample block comprises one or more recesses each configured to receive a sample vessel, wherein the shape of said at least one electrodeposited thermoelectric element is adapted to the shape of said one or more recesses.

2. The assembly according to claim 1 , wherein the electrodeposited thermoelectric element is disposed between the sample block and the heat sink.

3. The assembly according to claim 1 , wherein the electrodeposited thermoelectric element contacts one or more of the sample block and the heat sink.

4. The assembly according to claim 1 , wherein the sample block is fixed to the electrodeposited thermoelectric element and the heat sink.

5. The assembly according to claim 1 , wherein the sample block is fixed to the electrodeposited thermoelectric element and the heat sink by one or more of the following: a positive fit connection, a non-positive fit connection, and an adhesive bond connection.

6. The assembly according to claim 1 , wherein the sample block comprises at least one fixture hole, wherein the electrodeposited thermoelectric element comprises at least one first fixture hole and the heat sink comprises at least one additional fixture hole, wherein at least one threaded bolt engages the at least one first fixture hole of the sample block, the at least one first fixture hole of the electrodeposited thermoelectric element and the at least one additional fixture hole of the heat sink.

7. The assembly according to claim 1 , wherein the sample block comprises at least one recess configured to receive the sample vessel, wherein said recess comprises a bottom end and a recess through-hole positioned in the bottom end, wherein the electrodeposited thermoelectric element comprises at least one element through-hole, wherein the heat sink comprises at least one heat sink through-hole, wherein the recess through-hole, the element through-hole of the electrodeposited thermoelectric element and the heat sink through-hole of the heat sink are aligned on a common axis.

8. The assembly according to claim 1 , wherein the at least one first recess is tapered towards the electrodeposited thermoelectric element.

9. The assembly according to claim 1 , wherein the recess is conically shaped.

10. The assembly according to claim 1 , wherein the electrodeposited thermoelectric element comprises two or more thermoelectric zones, wherein the two or more thermoelectric zones are individually operable.

11. The assembly according to claim 10 , wherein the two or more thermoelectric zones comprise identical or different cooling and/or heating power characteristics.

12. The assembly according to claim 11 , wherein each of the two or more thermoelectric zones comprises sub-portions, wherein the sub-portions comprise the same or different cooling and/or heating power characteristics.

13. The instrument for performing a temperature-dependent reaction comprising an assembly according to claim 1 and at least one laboratory device.

14. A method of performing a temperature-dependent reaction in the assembly according to claim 1 , comprising exposing a sample comprised in the sample vessel disposed in a recess of the sample block to one or more specified temperatures by operating the electrodeposited thermoelectric element.

Assignees

• Roche Molecular Systems Inc

Inventors

• Ebert Sven
• Federer Paul
• Schlaubitz Thomas
• Vollenweider Stefan
• Wittenwiler Urs

Classifications

• H10W40/28

  comprising Peltier coolers · CPC title

• B01L3/5085

  for multiple samples, e.g. microtitration plates · CPC title

• B01L2300/1894

  Cooling means; Cryo cooling · CPC title

• G01N21/6402

  Atomic fluorescence; Laser induced fluorescence · CPC title

• B01L2300/0829

  Multi-well plates; Microtitration plates · CPC title