Ultraviolet Sterilizing Drainage Catheter

Patent metadata

Field	Value
Publication number	US-10183144-B2
Application number	US-201414535296-A
Country	US
Kind code	B2
Filing date	Nov 6, 2014
Priority date	Nov 6, 2013
Publication date	Jan 22, 2019
Grant date	Jan 22, 2019

Abstract

A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

First claim

What is claimed is:

1. A device, comprising a tubular member, wherein the tubular member is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler, the tubular member comprising:
a lumen defining a longitudinal interior space within the tubular member;
a tubular body bounded by
an inner wall facing the longitudinal interior space and defining an outer boundary of the lumen, and
an outer wall defining an outer surface of the tubular member;

at least one optical fiber disposed on the inner wall facing the longitudinal interior space and outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler and to emit UV light into the lumen along at least a portion of a length of the lumen; and
a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall.

2. The device of claim 1 , wherein:
the protective component is a UV reflective material disposed between the at least one optical fiber and the outer wall; or
the protective component is a UV reflective coating forming the outer wall.

3. The device of claim 2 , wherein the UV reflective material or UV reflective coating comprises at least one selected from the group comprising titanium, aluminum, chromium, iron, nickel, copper, zinc, palladium, silver, platinum and gold.

4. The device of claim 1 , wherein:
the tubular body comprises a UV transmissive inner section comprising the optical fiber embedded in a UV transmissive material and situated at or near the inner wall; and
the protective component comprises a UV absorbent outer section comprising a UV absorbent material situated at or near the outer wall.

5. The device of claim 4 , wherein the UV transmissive material is a silicone.

6. The device of claim 4 , wherein the UV absorbent material is a plastic commonly used in catheters.

7. The device of claim 1 , wherein the optical fiber is a diffusive optical fiber.

8. The device of claim 1 , wherein the optical fiber is a non-diffusive diffusive optical fiber configured to terminate at the portion of the length of the lumen to be illuminated.

9. The device of claim 1 , wherein the optical fiber is a bundle of optical fibers.

10. The device of claim 1 , wherein the optical fiber is disposed in a spiral configuration that is substantively coaxial with the lumen.

11. The device of claim 1 , further comprising:
a port in fluid communication with the lumen and situated at a proximal end of the tubular member; and
an opening in fluid communication with the lumen and situated at a distal end of the tubular member.

12. The device of claim 1 , further comprising at least one light source adapted to emit the UV light to illuminate the UV illumination coupler.

13. The device of claim 12 , further comprising:
a power source;
a power socket adapted to transmit current from the power source to the light source; and
a current controller adapted to control current from the power source to the light source.

14. The device of claim 12 , wherein the light source is adapted to emit the UV light having a frequency of about 250 nm to about 300 nm.

15. The device of claim 12 , wherein the light source is selected from a group comprising a light emitting diode (LED), a laser diode (LD), a superluminescent light emitting diode (SLED), a nanodot LED, a quantum dot, a laser and a combination thereof.

16. A device, comprising a tubular member, wherein the tubular member is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler, the tubular member comprising:
a lumen defining a longitudinal interior space within the tubular member;
a tubular body bounded by
an inner wall facing the longitudinal interior space and defining an outer boundary of the lumen, and
an outer wall defining an outer surface of the tubular member;

at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler and to emit UV light into the lumen along at least a portion of a length of the lumen;
a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall; and

a collection bag adapted to receive a liquid from the lumen, wherein the collection bag comprises at least one collection bag optical fiber adapted to emit UV light into an interior space of the collection bag.

17. A method for producing the device of claim 1 , the method comprising:
affixing the at least one optical fiber to a flexible material to form a fiber-containing structure;
rolling the fiber-containing structure to form a rolled structure defining a hollow space corresponding to the longitudinal interior space;
sealing the rolled structure to form the tubular member; and
attaching the ultraviolet illumination coupler to the tubular member.

18. A treatment method using a device comprising a tubular member, wherein the tubular member is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler, the tubular member comprising a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall facing the longitudinal interior space and defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler and to emit UV light into the lumen along at least a portion of a length of the lumen and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall, the method comprising:
inserting a distal end and a portion of the tubular member into a body cavity, duct or vessel of a subject;
passing a liquid or a solid object through the lumen; and
transmitting the UV light through the UV illumination coupler to illuminate at least a portion of the longitudinal interior space with a sufficient dose of UV light to inactivate a therapeutically effective amount of infective agents.

19. The treatment method of claim 18 , wherein the therapeutically effective amount is a reduction of bacteria contained in the lumen by at least two orders of magnitude while producing no measurable UV-induced damage in tissues of the subject.

Assignees

• The Univ Of Maryland Baltimore
• Us Veterans Affairs

Inventors

• Tang Cha-Min
• Bigeleisen Paul E
• Galvagno Jr Samuel M
• Shirtliff Mark E

Classifications

• A61M25/0045

  multi-layered, e.g. coated (coating materials A61L29/08) · CPC title

• A61M25/04

  in the body, e.g. expansible {(A61M25/10, A61M16/0488 take precedence)} · CPC title

• A61M25/0043 Primary

  characterised by structural features · CPC title

• A61M25/0017 Primary

  specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections · CPC title

• A61L29/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title