System and method for enhancing sleep slow wave activity based on cardiac activity

Patent metadata

Field	Value
Publication number	US-10183142-B2
Application number	US-201414783114-A
Country	US
Kind code	B2
Filing date	Apr 1, 2014
Priority date	Apr 10, 2013
Publication date	Jan 22, 2019
Grant date	Jan 22, 2019

Abstract

The present disclosure pertains to a system and method for managing a sleep session of a subject. Managing the sleep session is based on cardiac activity in the subject during the sleep session. Cardiac activity, as monitored via one or more sensors worn on an extremity of the subject and/or placed at a distance from the subject, is used to determine periods of slow wave sleep. Sensory stimulation is delivered to the subject during the periods of slow wave sleep to enhance slow wave activity. Wearing a sensor on an extremity, and/or placing a sensor at a distance from the subject during sleep, as opposed to the subject wearing an EEG cap, is more comfortable for the subject.

First claim

The invention claimed is:

1. A system configured to manage a current sleep session of a subject, the system comprising:
one or more sensory stimulators configured to provide sensory stimuli to the subject;
one or more sensors configured to generate output signals conveying information related to a blood volume of the subject during the current sleep session, the one or more sensors including an optical sensor configured to be carried by an extremity of the subject, the optical sensor including:
a light source configured to light an area of skin on the extremity of the subject, wherein at least some of the light is absorbed by blood in blood vessels of the area of skin; and
a photodiode assembly configured to generate output signals indicating an amount of light from the light source not absorbed by the blood in the blood vessels in the area of skin, the amount of light not absorbed being related to blood volume of the blood vessels in the area of skin; and

one or more processors configured to execute computer program modules, the computer program modules comprising:
a parameter module configured to determine a blood volume metric, the blood volume metric being related to a current sleep stage of the subject during the current sleep session;
a sleep stage module configured to determine the current sleep stage of the subject based on the blood volume metric, the sleep stage module configured to determine whether the subject is presently in slow wave sleep; and

a control module configured to control the one or more sensory stimulators to provide the sensory stimuli to enhance slow wave activity in the subject while the subject is determined to be in slow wave sleep.

2. The system of claim 1 , wherein the optical sensor is configured such that the extremity of the subject includes an arm, a leg, a wrist, a finger, an ankle, or a toe of the subject.

3. The system of claim 1 , wherein the one or more sensors include a camera placed at a distance from the subject and directed toward an area of the body of the subject, the camera configured to generate output signals related to changes in a color of the skin in the area of the body of the subject, the color of the skin being related to one or more of a pulse rate or a blood volume of blood vessels in the area of the body of the subject that the camera is directed towards.

4. The system of claim 1 , wherein the sleep stage module is configured such that slow wave sleep corresponds to a sleep stage N3.

5. The system of claim 1 , wherein the one or more sensors are further configured to generate output signals conveying information related to arousals of the subject, the arousals being related to wakefulness in the subject,
wherein the parameter module is further configured to determine an arousal metric based on the output signals conveying information related to arousals of the subject, and
wherein, responsive to the arousal metric indicating that the subject is waking up, the control module is configured to control the one or more sensory stimulators to cease providing the sensory stimuli to the subject.

6. A method for providing sensory stimulation to a subject with a management system, the system comprising one or more sensory stimulators, one or more sensors, and one or more processors configured to execute computer program modules, the computer program modules comprising a parameter module, a sleep stage module, and a control module, the method comprising:
generating output signals conveying information related to a blood volume of the subject during the current sleep session with the one or more sensors, wherein the one or more sensors include an optical sensor configured to be carried by an extremity of the subject, the optical sensor including a light source and a photodiode assembly;
lighting, with the light source, an area of skin on the extremity of the subject, wherein at least some of the light is absorbed by blood in blood vessels of the area of skin; and
generating, with the photodiode assembly, output signals indicating an amount of light from the light source not absorbed by the blood in the blood vessels in the area of skin, the amount of light not absorbed being related to blood volume of the blood vessels in the area of skin;
determining, with the parameter module, a blood volume metric, the blood volume metric being related to a current sleep stage of the subject during the current sleep session;
determining, with the sleep stage module, the current sleep stage of the subject based on the blood volume metric;
determining, with the sleep stage module, whether the subject is presently in slow wave sleep; and
controlling, with the control module, the one or more sensory stimulators to provide sensory stimuli to the subject to induce slow wave activity in the subject while the subject is determined to be in slow wave sleep.

7. The method of claim 6 , wherein the extremity of the subject includes an arm, a leg, a wrist, a finger, an ankle, or a toe of the subject.

8. The method of claim 6 , wherein the one or more sensors include a camera placed at a distance from the subject and directed toward an area of the body of the subject, the method further comprising generating, with the camera, output signals related to changes in a color of the skin in the area of the body of the subject, the color of the skin being related to one or more of a pulse rate or the blood volume of blood vessels in the area of the body of the subject that the camera is directed towards.

9. The method of claim 6 , wherein slow wave sleep corresponds to a sleep stage N3.

10. The method of claim 6 , further comprising generating output signals conveying information related to arousals of the subject, the arousals being related to wakefulness in the subject,
determining an arousal metric based on the output signals conveying information related to arousals of the subject, and
responsive to the arousal metric indicating that the subject is waking up, controlling the one or more sensory stimulators to cease providing the sensory stimuli to the subject.

11. A system configured to manage a current sleep session of a subject, the system comprising:
means for providing sensory stimuli to the subject;
means for generating output signals conveying information related to a blood volume of the subject during the current sleep session the means for generating output signals including optical sensing means configured to be carried by an extremity of the subject, the optical sensing means including:
means for lighting an area of skin on the extremity of the subject, wherein at least some of the light is absorbed by blood in blood vessels of the area of skin; and
means for generating output signals indicating an amount of light from the light source not absorbed by the blood in the blood vessels in the area of skin, the amount of light not absorbed being related to blood volume of the blood vessels in the area of skin;

means for determining a blood volume metric, the blood volume metric being related to a current sleep stage of the subject during the current sleep session;
means for determining the current sleep stage of the subject based on the blood volume metric, the means for determining the current sleep stage configured to determine whether the subject is presently in slow wave sleep; and
means for controlling the means for providing sensory stimuli to provide the sensory stimuli to the subject to induce slow wave activity in the subject while the subject is determined to be in slow wave sleep.

12. The system of claim 11 , wherein the optical sensing means are configured such that the extremity of the subject includes an arm, a leg

Assignees

• Koninklijke Philips Nv

Inventors

• Garcia Molina Gary Nelson
• Presura Cristian Nicolae
• Pfundtner Stefan
• Pastoor Sander Theodoor

Classifications

• A61B5/6826

  Finger · CPC title

• A61M2230/10

  Electroencephalographic signals · CPC title

• A61B5/6829

  Foot or ankle · CPC title

• A61M21/02 Primary

  for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia (for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021) · CPC title

• A61M2230/04

  Heartbeat characteristics, e.g. ECG, blood pressure modulation · CPC title