Substituted sulfonamide compounds

Patent metadata

Field	Value
Publication number	US-10179782-B2
Application number	US-201615042310-A
Country	US
Kind code	B2
Filing date	Feb 12, 2016
Priority date	Feb 15, 2015
Publication date	Jan 15, 2019
Grant date	Jan 15, 2019

Abstract

The invention is concerned with the compounds of formula I:

and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

First claim

We claim:

1. A compound selected from:

or a pharmaceutically acceptable salt thereof.

2. The compound:

or a pharmaceutically acceptable salt thereof.

3. The compound:

or a pharmaceutically acceptable salt thereof.

4. The compound:

or a pharmaceutically acceptable salt thereof.

5. The compound:

or a pharmaceutically acceptable salt thereof.

6. The compound:

or a pharmaceutically acceptable salt thereof.

7. The compound:

or a pharmaceutically acceptable salt thereof.

8. The compound:

or a pharmaceutically acceptable salt thereof.

9. The compound:

or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition, comprising a compound as described in claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

Assignees

• Genentech Inc

Inventors

• Estrada Anthony
• Villemure Elisia
• Verma Vishal
• Shore Daniel
• Volgraf Matthew
• Hu Baihua
• Lu Aijun

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P27/16

  Otologicals · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title