N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US-2017305847-A1 · Oct 26, 2017 · US
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US10179765B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10179765-B2 |
| Application number | US-201815961441-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 24, 2018 |
| Priority date | Mar 17, 2006 |
| Publication date | Jan 15, 2019 |
| Grant date | Jan 15, 2019 |
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Abstract
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The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
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for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title
Antiarrhythmics · CPC title
Antihyperlipidemics · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title
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- What does patent US10179765B2 cover?
- The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physi…
- Who is the assignee on this patent?
- Cardioxyl Pharmaceuticals Inc, Univ Johns Hopkins
- What technology area does this patent fall under?
- Primary CPC classification A61K31/18. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).