Nanoparticulate contrast agent

Patent metadata

Field	Value
Publication number	US-10179178-B2
Application number	US-201314423994-A
Country	US
Kind code	B2
Filing date	Aug 27, 2013
Priority date	Aug 27, 2012
Publication date	Jan 15, 2019
Grant date	Jan 15, 2019

Abstract

Provided is a nanoparticulate composite with two layers. One of the layers comprises one or more metals, which are a paramagnetic metal, a ferromagnetic metal, or a superparamagnetic metal. This layer also contains one or more suitable dopants. The other layer comprises one or more metals of gadolinium, manganese (II), and iron (III), in the form of an oxide or a fluoride. This layer may contain one or more lanthanide dopants. The nanoparticulate composite may be used as a contrast agent, in particular in magnetic resonance imaging.

First claim

What is claimed is:

1. A nanoparticulate composite comprising a first and a second layer,
wherein the first layer comprises one or more metals and one or more dopants, wherein the one or more metals comprise dysprosium (III) as a paramagnetic metal, and the one or more dopants comprise an Yb 3+ dopant; and
wherein the second layer comprises gadolinium (III), being an oxide, a fluoride or a phosphate, and an Yb 3+ dopant and an Er 3+ dopant.

2. The nanoparticulate composite of claim 1 , wherein the one or more metals comprised in the first layer are an oxide or a fluoride.

3. The nanoparticulate composite of claim 1 , wherein the one or more metals comprised in the first layer comprise one or more of Dy 2 O 3 , DyF 3 , NaDyF 4 , LiDyF 4 , and KDyF 4 .

4. The nanoparticulate composite of claim 1 , wherein the second layer comprises one or more of GdF 3 , Gd 2 O 3 , GdPO 4 , LiGdF 4 , NaGdF 4 , and KGdF 4 .

5. The nanoparticulate composite of claim 1 , wherein the second layer comprises one or more further lanthanide dopants.

6. The nanoparticulate composite of claim 5 , wherein the further dopant comprised in the second layer is one or more dopants of Tm 3+ , and Ho 3+ .

7. The nanoparticulate composite of claim 1 , being a core/shell nanocrystal or a heterodimer.

8. The nanoparticulate composite of claim 7 , being a core/shell nanocrystal, wherein the first layer defines the core, and the second layer defines the shell.

9. The nanoparticulate composite of claim 8 , comprising a surfactant immobilized on the core/shell nanocrystal surface.

10. A contrast agent comprising one or more nanoparticulate composites according to claim 1 .

11. The contrast agent of claim 10 , being a T 1 -T 2 dual mode MRI contrast agent.

12. The contrast agent of claim 10 , further being configured, upon exposure to a first wavelength λ 1 of radiation, to generate a second wavelength λ 2 of radiation having a higher energy than the first wavelength λ 1 .

13. A method of performing magnetic resonance imaging or upconversion fluorescence imaging, the method comprising contacting a nanoparticulate composite of claim 1 with a sample and performing magnetic resonance imaging or upconversion fluorescence imaging on the sample.

14. The method of claim 13 , wherein the sample is an organ or a tissue of a mammal.

15. The method of claim 13 , wherein the sample is exposed to a magnetic field applied for magnetic resonance imaging.

Assignees

• Univ Nanyang Tech
• Nanyang Technology Univ

Inventors

• Tan Thatt Yang Timothy
• Zhang Yan

Classifications

• A61K49/183 Primary

  having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus · CPC title

• A61K49/1818

  particles, e.g. uncoated or non-functionalised microparticles or nanoparticles · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K49/06

  Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title