Specific A-beta species-binding peptides for the therapy and/or diagnosis of Alzheimer's dementia

Patent metadata

Field	Value
Publication number	US-10174097-B2
Application number	US-201615549725-A
Country	US
Kind code	B2
Filing date	Feb 25, 2016
Priority date	Mar 20, 2015
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

The invention relates to peptides binding specifically to Abeta species for treating and/or diagnosing Alzheimer's disease.

First claim

The invention claimed is:

1. A peptide binding specifically to amyloid beta species, containing at least one amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10 and SEQ ID NO: 11.

2. The peptide of claim 1 for use in medicine.

3. The peptide of claim 1 for treating Alzheimer's disease.

4. The peptide of claim 1 for diagnosing Alzheimer's disease.

5. The peptide of claim 1 substantially composed of D-amino acids.

6. The peptide of claim 1 for inhibiting the formation of Abeta fibrils.

7. The peptide of claim 1 for binding to aggregated amyloid beta species.

8. A KIT, including a peptide according to claim 1 .

9. A composition comprising a peptide according to claim 1 .

10. A probe for specifically identifying and quantitatively and/or qualitatively determining amyloid beta monomers, amyloid beta fibrils and/or amyloid beta oligomers, comprising the peptide according to claim 1 .

Assignees

• Forschungszentrum Juelich Gmbh

Inventors

• Willbold Dieter
• Kutzsche Janine
• Klein Antonia

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• C07K14/4713 Primary

  Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K14/705 Primary

  Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)} · CPC title