Antileishmanial compositions and methods of use

Patent metadata

Field	Value
Publication number	US-10174072-B2
Application number	US-201715411249-A
Country	US
Kind code	B2
Filing date	Jan 20, 2017
Priority date	Apr 22, 2011
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from Pentalinon andrieuxii . This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

First claim

What is claimed is:

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula:

wherein each of R 4a and R 4b is independently selected from hydrogen and C 1 -C 12 alkyl, and each of R 6a and R 6b is independently selected from hydrogen and C 1 -C 12 alkyl;
or a pharmaceutically acceptable salt, solvate, or polymorph thereof;
wherein the pharmaceutically acceptable carrier is selected from the group consisting of a liposome, nanoparticle, microparticle, cyclodextrin, nanoemulsion, microemulsion, polymersome, surfactant, biocompatible organic solvent, and micelle,
wherein the composition is sterile.

2. The composition of claim 1 , wherein the compound is selected from:

3. The composition of claim 1 , wherein the compound is:

4. The composition of claim 1 , wherein the pharmaceutically acceptable carrier is a liposome.

5. The composition of claim 4 , wherein the liposome comprises a phospholipid.

6. The composition of claim 4 , wherein the liposome comprises one or more lipids selected from phosphatidylcholine, tocopherol, cholesterol, and 1,2-distearoyl-phosphatidyl ethanolamine-methyl-polyethylene glycol conjugate.

7. The composition of claim 4 , wherein the liposome comprises phosphatidylcholine and tocopherol.

8. The composition of claim 1 , wherein the pharmaceutically acceptable carrier is a biocompatible organic solvent comprising propylene glycol, polyethylene glycol, ethanol, dimethyl sulfoxide, N-methyl-2-pyrrolidone, glycofurol, 2,2-dimethyl-1,3-dioxolane-4-methanol (Solketal™), glycerol formal, acetone tetrahydrofurfuryl alcohol, diglyme, dimethyl isosorbide, cremophor, or ethyl lactate.

9. The composition of claim 1 , wherein the pharmaceutically acceptable carrier is a surfactant comprising a phospholipid, a poloxamer, or a polysorbate.

10. The composition of claim 1 , wherein the composition is in the form of a powder, a granule, a solution, a suspension in an aqueous liquid, a non-aqueous liquid, an oil-in-water emulsion or a water-in-oil liquid emulsion.

11. The composition of claim 1 , wherein the pharmaceutically acceptable carrier is a microemulsion or nanoemulsion.

12. The composition of claim 11 , wherein the microemulsion or nanoemulsion comprises an oil, surfactant, and aqueous phase.

13. The composition of claim 12 , wherein the oil comprises soybean oil or castor oil.

14. The composition of claim 12 , wherein the surfactant comprises tween or span.

15. The composition of claim 1 , further comprising at least one additional therapeutic agent.

16. The composition of claim 15 , wherein the at least one additional therapeutic agent comprises a vaccine.

Assignees

• Ohio State Innovation Foundation

Inventors

• Satoskar Abhay R
• Fuchs James F
• Kinghorn Alan Douglas
• Pan Li
• Lezama-Davila Claudio M
• Bachelder Eric

Classifications

• A61K9/10

  Dispersions; Emulsions · CPC title

• A61K9/2059

  Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin · CPC title

• A61K9/1271

  Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title

• A61K47/44

  Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) · CPC title

• A61K47/40

  Cyclodextrins; Derivatives thereof · CPC title