Therapeutic apparatus

Patent metadata

Field	Value
Publication number	US-10173077-B2
Application number	US-200913131476-A
Country	US
Kind code	B2
Filing date	Nov 19, 2009
Priority date	Dec 12, 2008
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

A therapeutic apparatus comprising: a magnetic resonance imaging system adapted for acquiring a set of magnetic resonance imaging data in an imaging zone, wherein the magnetic resonance imaging system comprises a means for generating a magnetic field, a guiding means adapted for guiding a beam of charged particles to a target zone within a subject such that the beam encloses an angle with the magnetic field lines of the magnetic field within the imaging zone, the angle being between 0 degrees and 30 degrees, wherein the imaging zone comprises the target zone, a zone determination means for determining the location of the target zone within the subject using the set of magnetic resonance imaging data.

First claim

The invention claimed is:

1. A therapeutic apparatus comprising:
a magnetic resonance imaging generator configured to:
acquire magnetic resonance images in an imaging zone,
include first and second sub magnets located above and below the imaging zone, each sub magnet surrounding a respective central region, the imaging zone surrounding a portion of a subject that includes a target zone, and
generate a magnetic field having magnetic field lines passing through the central regions of the first and second sub magnets;

a beam guide configured to guide a beam of charged particles along a path to the target zone, in the imaging zone the path and magnetic field lines of the magnetic field form an angle greater than 0 degrees and less than 30 degrees;
a processor configured to:
determine a location of the target zone within the subject using the magnetic resonance images,
determine effects on the beam of charged particles caused by the magnetic field using magnetic field data descriptive of the magnetic field; and
calculate a trajectory of the path based at least upon the effects on the beam of charged particles caused by the magnetic field; and

a beam controller configured to control the beam guide using the calculated trajectory to guide the beam along the calculated trajectory;
wherein the first sub magnet has an external surface facing away from the magnetic field generator that intersects a first central surface that surrounds the central region of the first magnet, wherein there is a beveled surface between the external surface and the first central surface which allows the beam to pass.

2. A therapeutic apparatus comprising:
a magnetic resonance imaging generator having first and second sub magnets located above and below an imaging zone, each sub magnet surrounding a respective central region, for acquiring a set of magnetic resonance imaging data in the imaging zone, and for generating a magnetic field having magnetic field lines passing through the central regions of the first and second sub magnets;
a beam guide for guiding a beam of charged particles along a path to a target zone within a subject, in the imaging zone the path and the magnetic field lines of the magnetic field form an angle greater than 0 degrees and less than 30 degrees;
a processor configured to:
determine a location of the target zone within the subject using the set of magnetic resonance imaging data, and
calculate a trajectory of the path of the beam using magnetic field data descriptive of the magnetic field; and

a beam controller configured to control the beam guide using the calculated trajectory such that the beam follows the calculated trajectory;
wherein the first sub magnet has an external surface facing away from the magnetic field generator that intersects a first central surface that surrounds the central region of the first magnet, wherein there is a beveled surface between the external surface and the first central surface which allows the beam to pass.

3. The therapeutic apparatus of claim 1 , wherein the processor is further configured to:
calculate an energy loss of the beam within the subject, and
adjust the calculated trajectory using the energy loss.

4. The therapeutic apparatus of claim 1 , wherein in the imaging zone, the path and the magnetic field lines of the magnetic field form an angle selected from ranges of between 5 degrees and 25 degrees, the calculated trajectory of the beam comprises more than one calculated trajectory, and the beam controller is configured to switch between the more than one calculated trajectory during therapy to minimize the exposure of portions of the subject outside of the target zone to the beam.

5. The therapeutic apparatus of claim 1 , wherein:
the magnetic resonance imaging generator is further configured to acquire magnetic resonance images at periodic intervals;
the processor is further configured to:
monitor motion of the target zone using the magnetic resonance images acquired at periodic intervals,
monitor internal motion of the subject along the beam trajectory using the magnetic resonance images acquired at periodic intervals, and
adjust the calculation of the calculated trajectory to compensate for motion of the target zone, and

the beam controller is configured to adjust the beam trajectory using adjustments to the calculated trajectory.

6. The therapeutic apparatus of claim 1 , wherein the beam guide comprises:
charged particle optics for adjusting the beam trajectory, and
an adjustable attenuator for modulating the energy of charged particles comprising the beam.

7. The therapeutic apparatus of claim 1 , wherein the magnetic resonance imaging system is further configured to measure the trajectory of charged particles within the imaging zone, wherein the beam controller is configured to adjust the beam trajectory using the measured trajectory.

Assignees

• Overweg Johannes Adrianus
• Koninl Philips Electronics Nv

Inventors

• Overweg Johannes Adrianus

Classifications

• A61N5/1049 Primary

  for verifying the position of the patient with respect to the radiation beam · CPC title

• A61N5/1037

  taking into account the movement of the target, e.g. 4D-image based planning · CPC title

• A61N2005/1055

  using magnetic resonance imaging [MRI] · CPC title

• A61N5/1038

  taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy · CPC title

• A61N2005/1087

  Ions; Protons · CPC title