Modular dialysate regeneration assembly

Patent metadata

Field	Value
Publication number	US-10172991-B2
Application number	US-201514644820-A
Country	US
Kind code	B2
Filing date	Mar 11, 2015
Priority date	Jun 24, 2014
Publication date	Jan 8, 2019
Grant date	Jan 8, 2019

Abstract

A customizable modular dialysate regeneration assembly with connectable sorbent packaging systems. The dialysate regeneration assembly can be customized based on patient parameters or dialysis session parameters. A processor can be included that can determine the correct amount of each sorbent material necessary for a given patient and a given dialysis session.

First claim

We claim:

1. A modular dialysate regeneration assembly, comprising:
a sorbent cartridge comprising a plurality of sorbent compartments each containing at least one sorbent material wherein each of the plurality of sorbent compartments are attachable to another sorbent compartment to form the modular dialysate regeneration assembly; and
a processor programmed to determine an amount and type of sorbent material in each sorbent compartment for a patient, the modular dialysate regeneration assembly having a desired dialysate regeneration profile based on one or more dialysis parameters and/or one or more patient parameters wherein the processor determines the amount and type of sorbent material in each sorbent compartment of the dialysate regeneration profile based on the dialysis parameters and/or the patient parameters.

2. The modular dialysate regeneration assembly of claim 1 , wherein the plurality of sorbent compartments have one or more sizes wherein any sized sorbent compartment is attachable to any other sized sorbent compartment.

3. The modular dialysate regeneration assembly of claim 1 , wherein at least one of the plurality of sorbent compartments has a circular or rectangular planar base having a wall extending perpendicularly and upwardly from said base defining an internal area; and
a circular or substantially rectangular planar top matching the planar base wherein the sorbent compartment has an engagement configuration selected from any one of:
(i) the base cooperatively engaging with the top of another sorbent compartment and the top cooperatively engaging with the base of another sorbent compartment;
(ii) the base not cooperatively engaging with the top of another sorbent compartment and the top cooperatively engaging with the base of another sorbent compartment;
(iii) the base cooperatively engaging with the top of another sorbent compartment and the top not cooperatively engaging with the base of another sorbent compartment; and
(iv) the base not cooperatively engaging with the top of another sorbent compartment and the top not cooperatively engaging with the base of another sorbent compartment.

4. The modular dialysate regeneration assembly of claim 1 , wherein the plurality of sorbent compartments are selected from any combination or number of compartments from a selected group of:
(i) a first sorbent compartment having a sorbent weight ranging from 0.1 kg to 0.5 kg;
(ii) a second sorbent compartment having a sorbent weight ranging from 0.5 kg to 1.0 kg;
(iii) a third sorbent compartment having a sorbent weight ranging from 1.0 kg to 1.5 kg;
(iv) a fourth sorbent compartment having a sorbent weight ranging from 1.5 kg to 2.0 kg;
(v) a fifth sorbent compartment having a sorbent weight ranging from 2.0 kg to 2.5 kg;
(vi) a sixth sorbent compartment having a sorbent weight ranging from 2.5 kg to 3.0 kg;
(vii) a seventh sorbent compartment having a sorbent weight ranging from 3.0 kg to 3.5 kg;
(viii) an eighth sorbent compartment having a sorbent weight ranging from 3.5 kg to 4.0 kg;
(ix) a ninth sorbent compartment having a sorbent weight ranging from 4.0 kg to 4.5 kg;
(x) a tenth sorbent compartment having a sorbent weight ranging from 4.5 kg to 5.0 kg; and
(xi) an eleventh sorbent compartment having a sorbent weight ranging from 0.0001 kg to 0.1 kg.

5. The modular dialysate regeneration assembly of claim 1 , wherein the plurality of sorbent compartments are selected from any combination or number of compartments from a selected group of:
(i) a first sorbent compartment having a volume ranging from 0.25 L to 1.3 L;
(ii) a second sorbent compartment having a volume ranging from 1.3 L to 2.5 L;
(iii) a third sorbent compartment having a volume ranging from 2.5 L to 3.7 L;
(iv) a fourth sorbent compartment having a volume ranging from 3.7 L to 5.0 L;
(v) a fifth sorbent compartment having a volume ranging from 5.0 L to 6.3 L;
(vi) a sixth sorbent compartment having a volume ranging from 6.3 L to 7.5 L;
(vii) a seventh sorbent compartment having a volume ranging from 7.5 L to 10 L;
(viii) an eighth sorbent compartment having a volume ranging from 0.01 L to 0.25 L; and
(ix) a ninth sorbent compartment having a volume ranging from 0.001 L to 0.01 L.

6. The modular dialysate regeneration assembly of claim 1 , wherein the at least one of the sorbent compartments has a planar base with upwardly extending walls connecting to a planar top wherein the walls are constructed from a rigid, fluid impermeable material.

7. The modular dialysate regeneration assembly of claim 6 , wherein either:
the base and top are circular and wherein the upwardly extending walls slope inward to an axis of the compartment wherein the top has a smaller surface area than the base or the upwardly extending walls slope outward from the axis wherein the top has a larger surface area than the base; or the base and top are rectangular having four upwardly extending walls sloping inward to an axis of the compartment wherein the top has a smaller surface area than the base or four upwardly extending walls sloping outward from the axis wherein the top has a larger surface area than the base.

8. The modular dialysate regeneration assembly of claim 6 , further comprising one or more of:
(i) an engagement member disposed on and extending upwardly from the planar top of the sorbent compartment;
(ii) a receiving groove disposed on the planar base of the sorbent compartment for receiving an engagement member;
(iii) an engagement member disposed on and extending downwardly from the planar base of the sorbent compartment; or
(iv) a receiving groove disposed on the planar top of the sorbent compartment for receiving an engagement member.

9. The modular dialysate regeneration assembly of claim 1 wherein the sorbent materials are selected from a group comprising activated carbon, ion exchange resin, hydrous zirconium oxide, alumina, urease, a mixture of alumina and urease, zirconium phosphate, and any combination thereof.

10. The modular dialysate regeneration assembly of claim 1 wherein the one or more dialysis parameters and/or one or more patient parameters are selected from a group comprising patient weight, concentration of one or more compounds in a blood sample from a patient, previous dialysis results of the patient, dialysis rate, length of dialysis session, a level of impurities in the water used, an expected amount of infusates to be added, and combinations thereof.

11. The modular dialysate regeneration assembly of claim 1 , wherein the sorbent compartments are sorbent pouches configurable into a stacked assembly of the sorbent pouches wherein each of the sorbent pouches is constructed in-part of a porous material forming the pouch containing inside the at least one sorbent material wherein the porous material allows fluid to pass through the sorbent pouch and substantially retains the at least one sorbent material in the sorbent pouch.

12. The modular dialysate regeneration assembly of claim 11 wherein the sorbent pouch is constructed from a material selected from a group comprising bolting cloth, porous polymer, porous metal, cotton, ashless filter paper, Dacron and polyethylene terephthalate.

13. The modular dialysate regeneration assembly of claim 1 , wherein each of the sorbent compartments is a distinct color depending on the sorbent material contained within the sorbent compartment.

14. The modular dialysate regeneration assembly of claim 3 , wherein at least one of the sorbent compartments contains urease and at least one of the sorbent compartments contains zirconium phosphate; wherein the engagement configurati

Assignees

• Medtronic Inc

Inventors

• Gerber Martin T
• Hobot Christopher M

Classifications

• A61M1/1613

  Profiling or modelling of patient or predicted treatment evolution or outcome · CPC title

• A61M2205/33

  Controlling, regulating or measuring · CPC title

• A61M2205/121

  interface between cassette and base · CPC title

• A61M1/1696 Primary

  with dialysate regeneration · CPC title

• A61M1/1611

  Weight of the patient · CPC title