Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US-9199005-B2 · Dec 1, 2015 · US
US10172884B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10172884-B2 |
| Application number | US-201715459478-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2017 |
| Priority date | Jun 16, 2015 |
| Publication date | Jan 8, 2019 |
| Grant date | Jan 8, 2019 |
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This document relates to bi-carbonate-buffered dialysis solutions with physiological phosphate content and increased stability. The solutions include an organic ester of phosphoric acid, calcium ions and/or magnesium ions, and optionally additional electrolytes, buffers and glucose in physiologically effective concentrations.
Opening claim text (preview).
What is claimed is: 1. A multi-chamber bag comprising two or more chambers, wherein a first chamber comprises a first solution that comprises one or more of calcium ions and magnesium ions; and a second chamber comprises a second solution that comprises an organic ester of phosphoric acid and bicarbonate ions, and does not contain calcium ions or magnesium ions, wherein the organic ester of phosphoric acid is glycerol orthophosphate. 2. The multi-chamber bag of claim 1 , wherein the first solution further comprises chloride ions, an osmotic agent; and wherein the second solution further comprises sodium ions and chloride ions. 3. The multi-chamber bag of claim 2 , wherein the first solution further comprises potassium ions. 4. The multi-chamber bag of claim 2 , wherein the first solution does not contain bicarbonate ions, organic esters of phosphoric acid, orthophosphate and sodium ions. 5. The multi-chamber bag of claim 2 , wherein the second solution does not contain calcium ions, magnesium ions, potassium ions, and osmotic agents. 6. The multi-chamber bag of claim 1 , wherein the first solution has a pH of about 2.4 to 3.0; and the second solution has a pH of about 7.0 to 7.8.
Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title
Phosphorus; Compounds thereof · CPC title
with two or more compartments · CPC title
Solutions {(composition of solutions A61K47/00)} · CPC title
Bag-type containers · CPC title
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