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Method for regenerating hair follicles using CD36-expressing dermal sheath cells
US10172332B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10172332-B2 |
| Application number | US-201615076836-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 22, 2016 |
| Priority date | Sep 29, 2010 |
| Publication date | Jan 8, 2019 |
| Grant date | Jan 8, 2019 |
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Abstract
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Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for regenerating hair follicles, comprising the step of transplanting a composition comprising CD36-expressing human dermal sheath cells to human skin, wherein the hair follicles are regenerated. 2. The method of claim 1 , wherein said composition is prepared by a process comprising the step of sorting CD36-expressing human dermal sheath cells from a human hair follicle tissue by use of a cell sorting technique using an antibody to CD36. 3. The method of claim 2 , wherein said composition further comprises human dermal papilla cells. 4. The method of claim 3 , wherein the ratio of the number of said CD36-expressing human dermal sheath cells to the number of said human dermal papilla cells is about 10:1 to 1:10. 5. The method of claim 1 , wherein said composition further comprises human dermal papilla cells. 6. The method of claim 5 , wherein the ratio of the number of said CD36-expressing human dermal sheath cells to the number of said human dermal papilla cells is about 10:1 to 1:10. 7. A method for regenerating hair follicles, comprising the steps of: preparing a composition comprising CD36-expressing human dermal sheath cells; and transplanting said composition to human skin, wherein the hair follicles are regenerated. 8. The method of claim 7 , wherein said composition is prepared by a process comprising the step of sorting CD36-expressing human dermal sheath cells from a human hair follicle tissue by use of a cell sorting technique using an antibody to CD36. 9. The method of claim 8 , wherein said composition further comprises human dermal papilla cells. 10. The method of claim 9 , wherein the ratio of the number of said CD36-expressing human dermal sheath cells to the number of said human dermal papilla cells is about 10:1 to 1:10. 11. The method of claim 7 , wherein said composition further comprises human dermal papilla cells. 12. The method of claim 11 , wherein the ratio of the number of said CD36-expressing human dermal sheath cells to the number of said human dermal papilla cells is about 10:1 to 1:10.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Animal model, e.g. for test or diseases · CPC title
Hair cells · CPC title
Hair stem cells; Hair progenitors (mesenchymal stem cells from hair follicles C12N5/0666) · CPC title
Chimeric vertebrates, e.g. comprising exogenous cells · CPC title
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Frequently asked questions
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- What does patent US10172332B2 cover?
- Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).
- Who is the assignee on this patent?
- Shiseido Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification A01K67/027. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 08 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).