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US-2024425855-A1 · Dec 26, 2024 · US
Methods for the treatment of cardiovascular fibrosis
US10167468B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10167468-B2 |
| Application number | US-201715420845-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 31, 2017 |
| Priority date | Sep 28, 2012 |
| Publication date | Jan 1, 2019 |
| Grant date | Jan 1, 2019 |
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- Title
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Abstract
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The present invention relates to methods and pharmaceutical compositions for the treatment of cardiovascular fibrosis. In particular, the present invention relates to an inhibitor of Neutrophil Gelatinase-Associated Lipocalin (NGAL) activity or expression for use in a method for treating or preventing cardiovascular fibrosis in a subject in need thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for treating cardiovascular fibrosis induced by aldosterone in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an inhibitor of Neutrophil Gelatinase-Associated Lipocalin (NGAL) activity, wherein the inhibitor of NGAL activity is an anti-NGAL antibody. 2. The method according to claim 1 , wherein the subject is at risk of developing heart failure. 3. The method according to claim 1 , wherein the inhibition of NGAL activity inhibits disease progression of cardiovascular fibrosis to heart failure.
Assignees
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Classifications
Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith {; Nucleic acids binding to non-nucleic acids, e.g. aptamers} · CPC title
interfering nucleic acids [NA] · CPC title
for enzymes or isoenzymes · CPC title
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links · CPC title
catalytic nucleic acids, e.g. ribozymes · CPC title
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- What does patent US10167468B2 cover?
- The present invention relates to methods and pharmaceutical compositions for the treatment of cardiovascular fibrosis. In particular, the present invention relates to an inhibitor of Neutrophil Gelatinase-Associated Lipocalin (NGAL) activity or expression for use in a method for treating or preventing cardiovascular fibrosis in a subject in need thereof.
- Who is the assignee on this patent?
- Inst Nat Sante Rech Med, Univ De Lorraine, Centre Hospitalier Et Univ De Nancy Chu, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).