Synthetic polymeric materials and devices thereof

Patent metadata

Field	Value
Publication number	US-10167387-B2
Application number	US-201414917795-A
Country	US
Kind code	B2
Filing date	Sep 10, 2014
Priority date	Sep 10, 2013
Publication date	Jan 1, 2019
Grant date	Jan 1, 2019

Abstract

Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

First claim

What is claimed is:

1. A polymeric material, comprising:
a polymer host comprising a silicone-based polymer; and
a guest molecule comprising hyaluronic acid or derivatives thereof;
wherein the guest molecule is disposed within the polymer host, and
wherein the guest molecule is covalently bonded to at least one other guest molecule, such that the covalently bonded guest molecules interpenetrate the polymer host molecules.

2. The polymeric material of claim 1 , wherein the silicone-based polymer comprises one or more polymers selected from the group consisting of poly(dimethylsiloxane) (PDMS), poly(methylvinylsiloxane) (PVMS), and epoxidized poly(methylvinylsiloxane) (ePVMS).

3. The polymeric material of claim 2 , wherein the silicone-based polymer is ePVMS, and the ePVMS has an average molecular weight of 3 kDa to 40 kDa before curing.

4. The polymeric material of claim 1 , wherein the silicone-based polymer comprises 3% to 40% vinyl groups per repeated monomeric unit.

5. The polymeric material of claim 1 , wherein the contact angle is between 80° and 130°.

6. The polymeric material of claim 1 , wherein percentage of covalently bonded guest molecules within the polymer host is 0.2% to 3.5% by weight.

7. The polymeric material of claim 1 , wherein average molecular weight of the covalently bonded guest molecule is 0.75 kDa to 10 kDa.

8. The polymeric material of claim 1 , wherein the polymeric material resists protein adsorption compared to the polymer host without the guest molecule disposed therein.

9. The polymeric material of claim 1 , wherein is light transmission is not substantially diminished compared to the polymer host without the guest molecule disposed therein.

Assignees

• Univ Colorado State Res Found

Inventors

• James Susan P
• Bailey Travis S
• Popat Ketul C
• Prawel David A
• Lewis Jackson T
• Koch Richard L

Classifications

• C08G77/388

  containing nitrogen · CPC title

• G02B1/043

  Contact lenses · CPC title

• A61F2002/1681

  having supporting structure for lens, e.g. haptics · CPC title

• A61F2/16

  Intraocular lenses · CPC title

• A61L27/44

  having a macromolecular matrix · CPC title