Medical apparatus and method for collecting biological samples

Patent metadata

Field	Value
Publication number	US-10166009-B2
Application number	US-201314646147-A
Country	US
Kind code	B2
Filing date	Nov 20, 2013
Priority date	Nov 20, 2012
Publication date	Jan 1, 2019
Grant date	Jan 1, 2019

Abstract

A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. In other embodiments, a valve is provided for opening and closing fluid communication with the filter membrane.

First claim

What is claimed is:

1. A biological filter system, comprising:
a filter membrane, the filter membrane having a top surface and a bottom surface; and
a border, the border having:
an upwardly extending sidewall circumscribing the filter membrane, the sidewall including a groove formed in the sidewall; wherein the border is composed of wax or machinable wax; and
a cover having a central portion and a flange circumscribing the central portion, the flange including a downwardly extending sidewall and a lip portion configured to matingly engage the groove;

wherein the filter membrane and border are each formed from material that is sliceable into sections suitable for mounting on a slide for microscopic analysis.

2. The biological filter system of claim 1 , wherein the central portion of the cover has a raised surface.

3. The biological filter system of claim 2 , wherein the raised surface is dome-shaped having an apex.

4. The biological filter system of claim 3 , wherein the apex is disposed below the flange.

5. The biological filter system of claim 1 , wherein the cover includes a plurality of ribs on a radially inner surface of the downwardly extending sidewall.

6. The biological filter system of claim 1 , wherein at least a portion of the upwardly extending sidewall includes undulating peaks and valleys or a planar surface on its periphery.

7. The biological filter system of claim 1 , wherein the filter membrane is composed of a porous material selected from the group consisting of polyethylene terephthalate and polycarbonate film.

8. The biological filter system of claim 1 , wherein the border is composed of an opaque material.

9. The biological filter system of claim 1 , wherein the border further includes a bottom surface having a plurality of apertures.

10. A biological filter system comprising:
a porous filter membrane, the porous filter membrane having a top surface and a bottom surface; and
a border, the border having a top surface and a bottom surface, wherein a bottom surface of the border is disposed proximate the bottom surface of the porous filter membrane, the border comprising:
an upwardly extending sidewall circumscribing the porous filter membrane, the sidewall including a radially inward projecting lip extending from a bottom portion of the sidewall, wherein the lip is configured to be coupled to the porous filter membrane, the sidewall further including a groove formed in the sidewall wherein the border is composed of wax or machinable wax; and
a cover having a central portion and a flange circumscribing the central portion, the flange including a downwardly extending sidewall and a downwardly extending lip portion configured to matingly engage the groove;

wherein the porous filter membrane and border are each formed from material that is sliceable into sections suitable for mounting on a slide for microscopic analysis.

11. The biological filter system of claim 10 , wherein at least a first portion of the upwardly extending sidewall includes undulating peaks and valleys on its periphery.

12. The biological filter system of claim 11 , wherein at least a second portion of the upwardly extending sidewall includes at least one planar surface on its periphery.

13. The biological filter system of claim 12 , wherein the cover includes a plurality of ribs on a radially inner surface of the downwardly extending sidewall.

14. The biological filter system of claim 10 , wherein the border comprises wax.

15. A biological filter system comprising:
a porous filter membrane, the filter membrane having a top surface and a bottom surface; and
a border, the border having:
an upwardly extending sidewall circumscribing the porous filter membrane, the sidewall including a groove formed in the sidewall; wherein the border is composed of wax or machinable wax; and
a cover having a central portion and a flange circumscribing the central portion, the flange including a downwardly extending sidewall and a lip portion configured to matingly engage the groove;

wherein the filter membrane and border are each formed from material that is sliceable into sections suitable for mounting on a slide for microscopic analysis.

16. The biological filter system of claim 15 wherein the border has a top surface and a bottom surface, wherein the bottom surface of the border is disposed proximate the bottom surface of the porous filter membrane, wherein the upwardly extending sidewall circumscribing the porous filter membrane, comprises a radially inward projecting lip extending from a bottom portion of the sidewall, wherein the lip is configured to be coupled to the porous filter membrane.

17. The biological filter system of claim 15 , wherein the central portion of the cover has a raised surface.

18. The biological filter system of claim 17 wherein the raised surface is dome-shaped having an apex, wherein the apex is disposed below the flange.

19. The biological filter system of claim 15 , wherein the cover includes a plurality of ribs on a radially inner surface of the downwardly extending sidewall.

20. The biological filter system of claim 1 , wherein at least a portion of the upwardly extending sidewall includes undulating peaks and valleys or a planar surface on its periphery.

Assignees

• Univ Columbia

Inventors

• Saqi Anjali
• Yeager Keith

Classifications

• B01L2300/0618

  for removable separation walls · CPC title

• B01L2300/0851

  Bottom walls · CPC title

• A61B10/02

  Instruments for taking cell samples or for biopsy {(A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48)} · CPC title

• B01L3/5021

  Test tubes specially adapted for centrifugation purposes · CPC title

• B01L2300/042

  Caps; Plugs · CPC title