Microfluidic device for high-volume production of monodisperse emulsions

Patent metadata

Field	Value
Publication number	US-10159979-B2
Application number	US-201415035222-A
Country	US
Kind code	B2
Filing date	Nov 11, 2014
Priority date	Nov 11, 2013
Publication date	Dec 25, 2018
Grant date	Dec 25, 2018

Abstract

A high volume microfluidic system for producing emulsions includes a fluid distribution network to produce uniformly sized emulsions and encapsulates.

First claim

What is claimed is:

1. A multi-layer microfluidic device for parallelization of microfluidic systems comprising:
plural layers arranged in top of each other; and
a distribution network including a plurality of channels to control the flow of a fluid,
the plural layers including first and second generator layers, made of plates or substrates, each of the first and second generator layer having a fractal pattern of fluid channels aligned between the layers by through-holes formed in each layer,
the plural layers further including (1) a dispersed phase distribution layer and (2) a continuous phase distribution layer, each of the dispersed phase distribution layer and the continuous phase distribution layer having a fractal pattern of fluid channels,
wherein the dispersed phase distribution layer receives a first fluid and allows the first fluid to flow through its fractal pattern of fluid channels,
the continuous phase distribution layer receives a second fluid, different from the first fluid, and allows the second fluid to flow through its fractal pattern of fluid channels,
the first and second fluids flow separately through the through-holes to the first generator layer and mix up and form an emulsion in the first generator layer and the emulsion flows through the fractal pattern of fluid channels of the first generator layer until arriving at an outlet, and
the first and second fluids flow separately through the through-holes to the second generator layer and mix up and form another emulsion in the second generator layer and the another emulsion flows through the fractal pattern of fluid channels of the second generator layer until arriving at the outlet.

2. The multi-layer microfluidic device of claim 1 , wherein the device comprises inputs that are accessible from a surface of the device.

3. The multi-layer microfluidic device of claim 1 , wherein the channels are on a substrate or plate made of polymeric plastic material such as poly(methyl-methacrylate), stainless steel, silicon, ceramics, or glass or a combination thereof.

4. The multi-layer microfluidic device of claim 1 , wherein the channels are in a pattern based on any number that follows the equation p×m×2 n , where p is an integer representing the number of petals, m is an integer representing the number of identical generation layers and n is an integer representing the number of levels of the fractal branching.

5. The multi-layer microfluidic device of claim 1 , further comprising at least one inlet or input and at least 1 outlet or output to allow accessibility of immiscible liquids and exit of droplets.

6. A method of forming an emulsion comprising:
inputting a first fluid at a dispersed phase distribution layer, which has a first fractal pattern of fluid channels, the first fluid flowing from an input to multiple ends of the first fractal pattern of fluid channels;
inputting a second fluid at a continuous phase distribution layer, which has a second fractal pattern of fluid channels, the second fluid flowing from another input to multiple ends of the second fractal pattern of fluid channels;
passing the first and second fluids through a multi-layer device comprising, in addition to the dispersed phase distribution layer and the continuous phase distribution layer, at least first and second generator layers,
wherein the first and second generator layers are connected by through-holes, and
wherein each of the first and second generator layer includes a corresponding fractal pattern;
mixing the first and second fluids to form the emulsion, in the first and second generator layers; and
controlling the flow of the emulsion, through the fractal pattern of fluid channels of the first and second generator layers, to an outlet that dispenses the emulsion.

7. The method of claim 6 , wherein the emulsion is monodisperse.

8. The method of claim 6 , wherein the emulsion is polydisperse.

9. The method of claim 6 , further comprising:
supplying a fluid to a processing zone having a curved surface such that the fluid forms a layer free of side edges.

10. The method of claim 9 , wherein the processing zone includes a tube having a curved surface.

11. The method of claim 9 , further comprising aligning an emulsion output around a tube having a curved surface.

12. The method of claim 9 , further comprising thermally treating on the curved surface to form crystals and other monodisperse particles.

13. The method of claim 9 , further comprising UV treating on the curved surface to form crystals and other monodisperse particles.

14. The method of claim 9 , wherein the processing zone includes an open rounded surface.

15. The method of claim 6 , wherein each channel is connected to a sensor, wherein the sensor detects a change of a function of the channel and signals to shut down a malfunctioning channel.

Assignees

• Univ King Abdullah Sci & Tech

Inventors

• Foulds Ian G
• Conchouso González David
• Castro David

Classifications

• B01L2300/0803

  Disc shape · CPC title

• B01L3/502707

  characterised by the manufacture of the container or its components · CPC title

• B01L2200/0673

  Handling of plugs of fluid surrounded by immiscible fluid · CPC title

• B01L2200/14

  Process control and prevention of errors · CPC title

• B01L3/502784 Primary

  specially adapted for droplet or plug flow, e.g. digital microfluidics · CPC title