Functional polymer gel containing organic nanotubes and method for producing same

Patent metadata

Field	Value
Publication number	US-10159642-B2
Application number	US-201515317885-A
Country	US
Kind code	B2
Filing date	Jun 12, 2015
Priority date	Jun 12, 2014
Publication date	Dec 25, 2018
Grant date	Dec 25, 2018

Abstract

The purpose of the present invention is to provide: a functional polymer gel which is able to be practically used as an ocular lens having excellent transparency and mechanical strength by uniformly dispersing organic nanotubes in a polymer gel without the formation of agglomerates of the organic nanotubes in the case where the organic nanotubes are complexed into the polymer gel; and a method for producing this functional polymer gel. The above-mentioned purpose is achieved by: a functional polymer gel which is characterized by containing organic nanotubes and having a light transmittance of 80% or more; and a method for producing this functional polymer gel.

First claim

The invention claimed is:

1. A method for producing a functional polymer gel, comprising:
Step (1) of mixing an organic nanotube with a hydrophilic monomer in which the organic nanotube can be dispersed until a slurry-like material is produced, so as to obtain a slurry-like organic nanotube dispersion, wherein mixing is by shaking at 15 to 40° C. for 1 to 24 hours;
Step (2) of mixing the slurry-like organic nanotube dispersion with a monomer mixture containing a polymerizable monomer that is different from the hydrophilic monomer and a polymerization initiator to form a pre-polymerization solution;
Step (3) of subjecting the pre-polymerization solution to a copolymerization reaction to obtain a functional polymer; and
Step (4) of hydrating and allowing to swell the functional polymer to obtain a functional polymer gel.

2. The method for producing a functional polymer gel of claim 1 , wherein the slurry-like organic nanotube dispersion is a slurry-like organic nanotube dispersion in which the content of the organic nanotube is 60 mass % or less with respect to the hydrophilic monomer.

3. The method for producing a functional polymer gel of claim 1 , wherein the organic nanotube is an organic nanotube encapsulating a drug.

4. The method for producing a functional polymer gel of claim 1 further including the step of immersing the functional polymer gel in an aqueous drug solution to obtain a functional polymer gel having a functionality of sustained drug release.

5. The method for producing a functional polymer gel of claim 1 , wherein the organic nanotube is an organic nanotube in which a hydrophobic functional group is introduced onto a part of the inner surface.

Assignees

• Seed Co Ltd
• Aist

Inventors

• Yamazaki Yoshiko
• Sato Takao
• Ding Wuxiao
• Masuda Mitsutoshi
• Wada Momoyo

Classifications

• A61K47/42

  Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K9/0051 Primary

  Ocular inserts or implants · CPC title

• A61K9/0092

  Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes · CPC title

• A61K31/352

  condensed with carbocyclic rings, e.g. methantheline  {(cannabinoids A61K31/658)} · CPC title