Adjustable intraocular flow regulation

Patent metadata

Field	Value
Publication number	US-10159600-B2
Application number	US-201313771000-A
Country	US
Kind code	B2
Filing date	Feb 19, 2013
Priority date	Feb 19, 2013
Publication date	Dec 25, 2018
Grant date	Dec 25, 2018

Abstract

Methods and devices for adjusting or configuring the flow rate of an intraocular shunt are provided whereby hypotony can be avoided by increasing the flow rate through the device. In some embodiments, the device is a shunt that can have a first flow that can be modified to a second flow by modifying the shunt, such as by cutting the shunt. Additionally, one or more dissolvable portions can be present to provide an initial flow restriction and subsequent increase in flow over time.

First claim

What is claimed is:

1. A method of adjusting a flow rate of an intraocular shunt implanted in an eye, the method comprising:
determining a position of the shunt, the shunt having an open inlet end positioned in an anterior chamber of the eye and an open outlet end positioned in a location of lower pressure of the eye to permit aqueous humor to drain from the anterior chamber through the shunt; and
after determining the position, cutting off a tubular section of the open outlet end to separate the tubular section from the shunt, thereby increasing flow through the shunt.

2. The method of claim 1 , further comprising:
determining an intraocular pressure of the eye;
determining a target pressure drop necessary to achieve normal intraocular pressure; and
determining a target longitudinal length of the shunt based on the target pressure drop;
wherein the cutting comprises cutting the shunt to the target length.

3. The method of claim 2 , further comprising separating the tubular section from the shunt.

4. The method of claim 2 , further comprising removing the tubular section from the eye.

5. The method of claim 2 , wherein the shunt comprises a tapered lumen.

6. The method of claim 1 , wherein the shunt has a partially restrictive section and a main section, the partially restrictive section having a cross-sectional area less than a cross-sectional area of the main section, and wherein the tubular section is cut from the partially restrictive section and has a longitudinal length less than a longitudinal length of the partially restrictive section.

7. The method of claim 1 , wherein the implanted shunt provides a non-zero flow rate before the tubular section of the shunt is cut off, and wherein the cutting off a tubular section increases flow through the shunt from the non-zero flow rate.

8. A method of adjusting a flow rate of an intraocular shunt implanted in an eye, the method comprising:
determining a position of the shunt, the shunt having a main section extending from an anterior chamber of the eye toward a location of lower pressure of the eye, the shunt having an open-ended partially restrictive section positioned in the location of lower pressure of the eye, the partially restrictive section being dimensioned to have a first inner cross-sectional dimension, the main section being dimensioned to have a second inner cross-sectional dimension; and
after determining the position, cutting off at least a tubular section of the open-ended partially restrictive section from the main section such that the flow rate through the shunt increases.

9. The method of claim 8 , wherein the first inner cross-sectional dimension is less than the second inner cross-sectional dimension.

10. The method of claim 8 , wherein a ratio of an inner diameter to an axial length of the main section is less than a ratio of an inner diameter to an axial length of the partially restrictive section.

11. The method of claim 8 , wherein the cutting comprises removing the tubular section of the shunt, the tubular section of the shunt having a smaller diameter lumen than the main section.

12. The method of claim 8 , wherein the cutting comprises cutting the shunt using a mechanical device.

13. The method of claim 8 , wherein the cutting comprises cutting the shunt using a laser.

14. The method of claim 8 , further comprising removing the tubular section from the eye after cutting the tubular section from the shunt.

15. The method of claim 8 , further comprising leaving the tubular section in the eye after separating the tubular section from the shunt.

16. The method of claim 8 , wherein separating the tubular section comprises removing the tubular section from the eye and leaving a portion of the partially restrictive section attached to the shunt.

17. The method of claim 8 , further comprising:
determining an intraocular pressure of the eye;
determining a target pressure drop necessary to achieve normal intraocular pressure; and
determining a target longitudinal length of the partially restrictive section based on the target pressure drop;
wherein the cutting comprises cutting the partially restrictive section to the target length.

18. The method of claim 17 , wherein the shunt comprises a tapered lumen.

19. The method of claim 8 , wherein the cutting comprises cutting an entirety of the restrictive section from the main section.

20. The method of claim 8 , wherein the implanted shunt provides a non-zero flow rate before the tubular section of the shunt is cut off, and wherein the cutting off at least a tubular section increases flow through the shunt from the non-zero flow rate.

21. A method of adjusting a flow rate of an intraocular shunt implanted in an eye, the method comprising:
determining an intraocular pressure of the eye;
determining a target pressure drop necessary to achieve normal intraocular pressure in the eye, the shunt being implanted in the eye and extending between an open inlet end positioned in an anterior chamber of the eye and an open outlet end positioned in a location of lower pressure of the eye;
determining a target length of the shunt based on the target pressure drop; and
after determining the target length, cutting off a tubular portion of the open outlet end of the shunt to cut the shunt to the target length.

22. The method of claim 21 , further comprising separating the tubular portion from the shunt.

23. The method of claim 21 , further comprising removing the tubular portion from the eye.

24. The method of claim 21 , wherein the implanted shunt provides a non-zero flow rate before the tubular portion of the shunt is cut off, and wherein the cutting off a tubular portion increases flow through the shunt from the non-zero flow rate.

Assignees

• Aquesys Inc

Inventors

• Horvath Christopher
• Romoda Laszlo O
• Hamstrom Brian
• Bache Ronald D
• Grabner Guenther
• Reitsamer Herbert A

Classifications

• A61F9/00781 Primary

  Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment (drainage implants in general A61M27/002) · CPC title

• A61L31/08

  Materials for coatings · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61M2210/0612

  Eyes · CPC title

• A61M27/002

  Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202) · CPC title