System and method for image-based quantification of white and brown adipose tissue at the whole-body, organ and body-region levels

Patent metadata

Field	Value
Publication number	US-10157462-B2
Application number	US-201715634797-A
Country	US
Kind code	B2
Filing date	Jun 27, 2017
Priority date	Jun 27, 2016
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

A system and method for automatically detecting and quantifying adiposity distribution is presented herein. The system detects, segments and quantifies white and brown fat adipose tissues at the whole-body, body region, and organ levels.

First claim

What is claimed is:

1. A method of automatically detecting and quantifying white and brown adipose tissue from an imaging scan of a subject comprising:
providing the imaging scan of the subject wherein the imaging scan is created using computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT), positron emission tomography/magnetic resonance imaging (PET/MRI) or contrast-enhanced ultrasound (CEUS);
automatically detecting a body region of the subject in the imaging scan using extracted convolutional neural network (CNN) features;
segmenting total adipose tissue (TAT) in the body region;
separating and segmenting subcutaneous adipose tissue (SAT) from visceral adipose tissue (VAT) in the body region in the imaging scan of the subject comprising
estimating a SAT-VAT separation boundary;
removing outliers the separation boundary; and
creating a fine SAT-VAT separating surface using three-dimensional (3D) Conditional Random Fields (CRF) using shape, anatomy and appearance cues; and
detecting and segmenting brown adipose tissue (BAT) from other tissue after TAT segmentation in the imaging scan of the subject.

2. The method of claim 1 , wherein the body region detected is selected from the group consisting of an abdominal region and a thorax region.

3. The method of claim 2 , wherein the body region is automatically detected by using a detection algorithm based on deep learning features.

4. The method of claim 1 , wherein the outliers are removed from the boundary using geometric median absolute derivation (MAD) or local outlier scores (LoOS).

5. The method of claim 1 , wherein the detecting and segmenting of BAT step further comprises:
performing automatic seed selection for BAT;
delineating potential BAT regions; and
differentiating BAT regions from non-BAT regions.

6. The method of claim 5 , wherein fixed Hounsfield unit (HU) interval filtering is used to identify TAT.

7. The method of claim 5 , wherein background and foreground seeds are identified during automatic seed selection.

8. The method of claim 5 , wherein image co-segmentation using Random Walk (RW) is used to delineate potential BAT regions.

9. The method of claim 5 , wherein a probabilistic metric based on a combination of total variation and Cramer-Von Mises distances is used to differentiate BAT regions from non-BAT regions.

10. The method of claim 1 , further comprising automatically detecting specific organs comprising:
extracting 3D convolutional neural network (CNN) features from source data;
transforming 3D CNN features from source data to target data by applying Geodesic Flow Kernal (GFK) to the 3D CNN features; and
localizing the organ in a bounding volume using Random Forest;
wherein the target data is organ detection in 3D CT scans.

11. The method of claim 1 , wherein the imaging scan is selected from the group consisting of a positron emission tomography/computed tomography (PET/CT) scan, a positron emission tomography/magnetic resonance imaging scan (PET/MRI) and a contrast-enhanced ultrasound (CEUS) scan.

12. A method of creating a risk profile of a subject by automatically detecting and quantifying white and brown adipose tissue from an imaging scan of the subject comprising:
the imaging scan of the subject wherein the imaging scan is created using computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT), positron emission tomography/magnetic resonance imaging (PET/MRI) or contrast-enhanced ultrasound (CEUS);
automatically detecting a body region of the subject in the imaging scan using extracted convolutional neural network (CNN) features wherein the body region detected is an abdominal region or a thorax region;
segmenting total adipose tissue (TAT) in the body region;
separating and segmenting subcutaneous adipose tissue (SAT) from visceral adipose tissue (VAT) in the imaging scan of the subject comprising
estimating a SAT-VAT separation boundary;
removing outliers using geometric median absolute derivation (MAD) or local outlier scores (LoOS); and
creating a fine SAT-VAT separating surface using 3D Conditional Random Fields (CRF) using shape, anatomy and appearance cues;
detecting and segmenting brown adipose tissue (BAT) from other tissue after TAT segmentation in the imaging scan of the subject; and
creating a risk profile based on a quantitative amount of VAT and BAT found in the subject.

13. The method of claim 12 , wherein the detecting and segmenting brown adipose tissue (BAT) from other tissue step further comprising:
performing automatic seed selection for BAT;
performing image co-segmentation; and
differentiating BAT regions from non-BAT regions.

14. The method of claim 12 , further comprising automatically detecting specific organs comprising:
extracting 3D convolutional neural network (CNN) features from source data;
transforming 3D CNN features from source data to target data by applying Geodesic Flow Kernal (GFK) to the 3D CNN features; and
localizing the organ in a bounding volume using Random Forest;
wherein the target data is organ detection in 3D CT scans.

15. A method of automatically detecting and quantifying white and brown adipose tissue from an imaging scan of a subject comprising:
providing the imaging scan of the subject wherein the imaging scan is created using positron emission tomography/computed tomography (PET/CT);
automatically detecting a body region of the subject in the imaging scan using extracted convolutional neural network (CNN) features;
segmenting total adipose tissue (TAT) in the body region;
separating and segmenting subcutaneous adipose tissue (SAT) from visceral adipose tissue (VAT) in the imaging scan of the subject comprising:
estimating a SAT-VAT separation boundary;
removing outliers using geometric median absolute derivation (MAD) or local outlier scores (LoOS); and
creating a fine SAT-VAT separating surface using 3D Conditional Random Fields (CRF) using shape, anatomy and appearance cues;
detecting and segmenting brown adipose tissue (BAT) from other tissue after TAT segmentation in the imaging scan of the subject comprising:
performing automatic seed selection for BAT;
performing image co-segmentation; and
differentiating BAT regions from non-BAT regions.

16. The method of claim 15 , further comprising automatically detecting specific organs comprising:
extracting 3D convolutional neural network (CNN) features from source data;
transforming 3D CNN features from source data to target data by applying Geodesic Flow Kernal (GFK) to the 3D CNN features; and
localizing the organ in a bounding volume using Random Forest;
wherein the target data is organ detection in 3D CT scans.

Assignees

• Univ Central Florida Res Found Inc

Inventors

• Bagci Ulas
• Hussein Sarfaraz

Classifications

• G06T2207/20156

  Automatic seed setting · CPC title

• A61B6/50

  specially adapted for specific body parts; specially adapted for specific clinical applications · CPC title

• A61B6/037

  Emission tomography · CPC title

• G06T2207/10132

  Ultrasound image · CPC title

• G06T2207/20084

  Artificial neural networks [ANN] · CPC title