Sampling systems and methods of using the same

Patent metadata

Field	Value
Publication number	US-10156551-B2
Application number	US-201514850366-A
Country	US
Kind code	B2
Filing date	Sep 10, 2015
Priority date	Sep 12, 2014
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

A sampling system comprising an external sampling assembly in fluidic communication with a process sample manager is provided herein. The sampling system can automatically acquire sample from one or more sources of sample to prepare sample for injection into a column or detector. The external sampling assembly has an external sampling valve connected to an external pump and is in fluidic communication with a process sample manager. The external sampling valve has a first configuration and a second configuration useful in three steps of drawing, loading and discharging sample. Two selection valves can be connected to a plurality of external sampling valves for sequential sampling of multiple sources of sample. Sample can also be diluted in the process sample manager and then combined in a solvent composition stream for injection into the column or the detector.

First claim

I claim:

1. A sampling system configured to automatically acquire a sample from at least one non-pressurized source of the sample comprising: an external sampling assembly in fluidic communication with the at least one source of the sample, the external sampling assembly comprising an external sampling valve having a first sample loop and an external pump; and a process sample manager connected to the external sampling assembly, wherein the external sampling valve has a first configuration in which the external sampling valve is configured to place the process sample manager in fluidic communication with the first sample loop, and a second configuration in which the external sampling valve is configured to place the external pump in fluidic communication with the first sample loop.

2. The sampling system of claim 1 , the process sample manager is in fluidic communication with a column or a detector.

3. The sampling system of claim 1 , wherein the process sample manager comprises an online sampling valve connected to the external sampling valve.

4. The sampling system of claim 3 , wherein in the first configuration, the first sample loop of the external sampling valve is in fluidic communication with the online sampling valve.

5. The sampling system of claim 4 , the process sample manager further comprising a priming valve and a fluidic tee, wherein the priming valve is connected to the online sampling valve and the fluidic tee.

6. The sampling system of claim 5 , wherein the process sample manager further comprises a diluent source and a diluent pump wherein the diluent pump and the diluent source are connected to the priming valve and the diluent pump is in fluidic communication with the diluent source or the fluidic tee.

7. The sampling system of claim 6 , wherein the process pump is configured to be in fluidic communication with the external sampling assembly or the first wash reservoir.

8. The sampling system of claim 1 , wherein the process sample manager further comprises a process valve connected to a first wash reservoir and a process pump.

9. A sampling system configured to acquire sample from a plurality of non-pressurized sources of sample for injection into a column or detector comprising:
an external sampling assembly having a plurality of external sampling valves, at least two selection valves and an external pump, wherein each said external sampling valve comprises a first sample loop, each said external sampling valve having a first configuration in which the external sampling valve is configured to place the source of sample in fluidic communication with the external pump and a second configuration in which the external sampling valve is configured to place the external pump in fluidic communication with the first sample loop.

10. The sampling of claim 9 , wherein in the first configuration, the first sample loop is in fluidic communication with the at least two selection valves.

11. The sampling system of claim 10 , wherein the process sample manager is in fluidic communication with a solvent delivery system.

12. The sampling system of claim 9 , further comprising a process sample manager, wherein each of the at least two selection valves is connected to the process sample manager.

13. The sampling system of claim 12 , the process sample manager further comprising an online sampling valve connected to each said selection valve.

14. The sampling system of claim 13 wherein the process sample manager further comprises a priming valve and fluidic tee, wherein the online sampling valve is in fluidic communication with the priming valve and the fluidic tee.

15. The sampling system of claim 9 , wherein the process sample manager further comprises a process valve connected to the external sampling valve and the process valve is configured to discharge wash to the external sampling valve.

16. A sampling system configured to acquire sample from a plurality of non-pressurized sources of sample and discharge sample into a column or detector comprising:
an external sampling assembly having a plurality of external sampling valves, at least two selection valves, and an external pump, wherein each said external sampling valve has a first sample loop, a first configuration in which the external sampling valve is configured to place the source of sample in fluidic communication with the external pump and a second configuration in which the external sampling valve is configured to place the external pump in fluidic communication with the first sample loop; and
a process sample manager, wherein each of the at least two selection valves is connected to the process sample manager.

17. The sampling system of claim 16 , wherein in the first configuration, the selection valve is in fluidic communication with the first sample loop.

18. The sampling system of claim 16 , wherein the process sample manager comprises an online sampling valve connected to the at least two selection valves.

19. The sampling system of claim 18 , wherein in the first configuration, the first sample loop is in fluidic communication with the on-line sampling valve.

20. The sampling system of claim 19 , wherein the process sample manager is in fluidic communication with a solvent delivery system.

Assignees

• Waters Technologies Corp

Inventors

• Cormier Sylvain

Classifications

• G01N2030/202

  rotary valves · CPC title

• G01N30/20 Primary

  using a sampling valve · CPC title

• G01N30/24

  Automatic injection systems · CPC title