Microorganisms and methods for producing butadiene and related compounds by formate assimilation
US-2015050708-A1 · Feb 19, 2015 · US
Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms
US10155933B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10155933-B2 |
| Application number | US-201314417559-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 29, 2013 |
| Priority date | Jul 29, 2012 |
| Publication date | Dec 18, 2018 |
| Grant date | Dec 18, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
An isolated microorganism that expresses enzymes of the reductive glycine pathway is disclosed. The microorganism is capable of converting formate to pyruvate or glycerate via the formation of glycine and serine. Methods of generating same are further described.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated bacteria that is genetically modified to express enzymes of the reductive glycine pathway, said bacteria being able to utilize formate as its sole carbon source, wherein the bacteria is capable of converting formate to glycine and serine and further being able of converting said glycine and said serine to pyruvate or glycerate. 2. The bacteria of claim 1 , further expressing a formate dehydrogenase which is capable of reducing carbon dioxide to formic acid. 3. The bacteria of claim 1 , wherein said bacteria comprises Escherichia. 4. The Escherichia bacteria of claim 3 , wherein said Escherichia are genetically modified to express a first enzyme NAD-dependent formate dehydrogenase which is capable of oxidizing formate to carbon dioxide and a second enzyme formate-tetrahydrofolate ligase. 5. The bacteria of claim 4 , wherein said Escherichia are genetically modified to further express bifunctional methenyltetrahydrofolate-cyclohydrolase-NAD-dependent-methylenetetrahydrofolate-dehydrogenase. 6. The bacteria of claim 1 , being genetically modified to express a human polypeptide. 7. The bacteria of claim 1 , capable of producing a biofuel.
Assignees
Inventors
Classifications
with NAD or NADP as acceptor (1.5.1) · CPC title
Ligases (6) · CPC title
Formate dehydrogenase (1.2.1.2) · CPC title
Methylenetetrahydrofolate dehydrogenase (NAD+) (1.5.1.15) · CPC title
Methylenetetrahydrofolate dehydrogenase (NADP+) (1.5.1.5) · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10155933B2 cover?
- An isolated microorganism that expresses enzymes of the reductive glycine pathway is disclosed. The microorganism is capable of converting formate to pyruvate or glycerate via the formation of glycine and serine. Methods of generating same are further described.
- Who is the assignee on this patent?
- Yeda Res & Dev, Yeda Res & Dev
- What technology area does this patent fall under?
- Primary CPC classification C12N9/0008. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 18 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).