Photopolymerizable liquid composition

Patent metadata

Field	Value
Publication number	US-10155065-B2
Application number	US-201415104193-A
Country	US
Kind code	B2
Filing date	Dec 12, 2014
Priority date	Dec 13, 2013
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

The subject matter of the present invention is a photopolymerizable liquid composition comprising at least one epoxidized polybutadiene prepolymer, at least one cationic photoinitiator, and at least one thioxanthone-derived photosensitizer, which can, for example, be in the form of a liquid dressing. The subject matter of the invention is also a process for obtaining a polymerized film from said photopolymerizable liquid composition, characterized in that said composition is applied to tissues such as the skin, the skin appendages or the mucous membranes so as to form a uniform liquid film, and the film thus obtained is subjected to ultraviolet radiation, preferably ultraviolet-visible radiation having a wavelength of between 380 and 405 nm, preferably between 385 and 395 nm.

First claim

The invention claimed is:

1. A method of covering tissue with a polymerized film made from a polymerization liquid composition comprising: at least one epoxidized polybutadiene prepolymer, at least one cationic onium salt photoinitiator, and at least one thioxanthone derivative photosensitizer, wherein said method comprises
i. applying said composition to said tissue so as to form a uniform liquid film, and
ii. subjecting the film obtained in step i. to UV-visible radiation having a wavelength of between 380 and 405 nm; and
wherein said tissue is the skin, the skin appendages or mucous membranes.

2. The method of claim 1 wherein the thickness of the uniform liquid film is greater than 500 nm.

3. The method of claim 1 , wherein the film obtained in step i. is subjected to UV-visible radiation, for a period of between 5 seconds and 60 minutes.

4. The method of claim 1 wherein the thickness of the uniform liquid film is between 1 and 300 μm.

5. The method of claim 1 wherein the thickness of the uniform liquid film is between 2 and 200 μm.

6. The method of claim 1 , wherein said UV-visible radiation has a wavelength of between 385 and 395 nm.

7. The method of claim 1 , wherein the photopolymerizable liquid composition further comprises a second prepolymer.

8. The method of claim 7 , wherein the second prepolymer is a vegetable oil of natural origin functionalized with at least one cationically polymerizable epoxide group.

9. The method of claim 7 , wherein the second prepolymer is selected from the group consisting of epoxidized almond oil, epoxidized peanut oil, epoxidized argan oil, epoxidized rapeseed oil, epoxidized coconut oil, epoxidized linseed oil, epoxidized corn oil, epoxidized mustard oil, epoxidized olive oil, epoxidized palm oil, epoxidized grapeseed oil, epoxidized castor oil, epoxidized sesame oil, epoxidized soybean oil, epoxidized sunflower oil, and mixtures thereof.

10. The method of claim 1 , wherein the photopolymerizable liquid composition further comprises a hydrogen-donor compound.

11. The method of claim 10 , wherein the hydrogen-donor compound is a primary, secondary or tertiary alcohol.

12. The method of claim 10 , wherein the hydrogen-donor compound is selected from the group consisting of n-propanol, isopropanol, benzyl alcohol, t-butanol, and mixtures thereof.

Assignees

• Urgo Lab
• Univ Reims Champagne Ardenne
• Centre Nat Rech Scient
• Laboratories Urgo
• Center National De La Recherche Scient

Inventors

• Coqueret Xavier
• Das Sadananda
• Auguste Stéphane

Classifications

• A61K9/7007

  Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence) · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L26/0052

  Mixtures of macromolecular compounds · CPC title

• C08G59/027 Primary

  obtained by epoxidation of unsaturated precursor, e.g. polymer or monomer · CPC title