Use of a feed composition for reducing methane emission in ruminants, and/or to improve ruminant performance

Patent metadata

Field	Value
Publication number	US-10154981-B2
Application number	US-201214119990-A
Country	US
Kind code	B2
Filing date	May 25, 2012
Priority date	May 26, 2011
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the use of a feed composition or a feed additive comprising at least one antibiotic and at least one organic molecule substituted at any position with at least one nitrooxy group for reducing the production of methane emanating from the digestive activities of ruminants, and/or to improve the ruminant performance.

First claim

The invention claimed is:

1. A feed composition or feed additive for a ruminant animal comprising:
(i) at least one antibiotic, and
(ii) at least one organic molecule or a salt thereof which is selected from the group consisting of 3-nitrooxypropanol, rac-4-Phenylbutane-1,2-diyl dinitrate, 2-(hydroxymethyl)-2-(nitrooxymethyl)-1,3-propanediol, N-ethyl-3-nitro-oxy-propionic sulfonyl amide, 5-nitrooxy-pentanenitrile, 5-nitrooxy-pentane, 3-nitro-oxy-propyl propionate, 1,3-bis-nitrooxypropane, 1,4-bis-nitrooxybutane, 1,5-bis-nitrooxypentane, 3-nitro-oxy-propyl benzoate, 3-nitro-oxy-propyl hexanoate, 3-nitro-oxy-propyl 5-nitro-oxy-hexanoate, benzylnitrate, isosorbid-dinitrate, N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide, 3-nitrooxy propionic acid, methyl-3-nitrooxy propionate, ethyl-3-nitrooxy propionate, ethyl-4-nitrooxy butanoate, ethyl-3-nitrooxy butanoate, 5-nitrooxy pentanoic acid, ethyl-5-nitrooxy pentanoate, 6-nitrooxy hexanoic acid, ethyl-6-nitrooxy hexanoate, ethyl-4-nitrooxy-cyclohexylcarboxylate, 8-nitrooxy octanoic acid, ethyl-8-nitrooxy octanoate, 11-nitrooxy undecanoic acid, ethyl-11-nitrooxy undecanoate, 5-nitrooxy-pentanoic amide and 5-nitrooxy-N-methyl-pentanoic amide, wherein
the at least one organic molecule is present in an amount sufficient to reduce formation of methane emanating from digestive activities of the ruminant animal and/or to improve performance of the ruminant animal, and wherein
the at least one organic molecule and the at least one antibiotic are present in a weight ratio of the at least one organic molecule to the at least one antibiotic of between 0.05 and 50.

2. The feed composition or feed additive of claim 1 which is a form selected from the group consisting of a mineral premix, a vitamin premix, premix including vitamins and minerals, and a bolus.

3. The feed composition or feed additive of claim 1 , wherein the antibiotic is at least one selected from the group consisting of monensin, lasalocid, narasin, maduramycin, semduramycin, salinomycin, avoparcin, actaplanin, and penicillin.

4. The feed composition or feed additive of claim 1 , which further comprises at least one additional active substance selected from the group consisting of diallyl disulfide, garlic oil, allyl isothiocyanate, deoxycholic acid, chenodeoxycholic acid and derivatives thereof.

5. The feed composition or feed additive of claim 1 , wherein the ruminant animal is selected from the group consisting of cattle, goats, sheep, giraffes, American Bison, European bison, yaks, water buffalo, deer, camels, alpacas, llamas, wildebeest, antelope, pronghorn, and nilgai.

6. The feed composition or feed additive of claim 1 , wherein the organic molecule is present in an amount sufficient to reduce formation of methane emanating from digestive activities of ruminants calculated in liters per kilogram of dry matter intake by at least 10% when measured in metabolic chambers.

7. The feed composition or feed additive of claim 1 , wherein the amount of the at least one organic molecule is present in an amount of 1 mg to 10 g per kg feed.

8. The feed composition or feed additive of claim 1 , wherein the amount of the at least one antibiotic is present in an amount from 0.5 to 150 mg per kg feed.

9. A feed composition or feed additive for a ruminant animal comprising:
(i) at least one antibiotic, and
(ii) at least one nitrooxy compound or salt thereof selected from the group consisting of 3-nitrooxy propanol, ethyl-3-nitrooxy propionate, methyl-3-nitrooxy propionate, and 3-nitrooxy propionic acid in an amount sufficient to reduce formation of methane emanating from digestive activities of the ruminant animal calculated in liters per kilogram of dry matter intake by at least 10% when measured in metabolic chambers.

10. The feed composition or feed additive as in claim 9 , wherein the at least one nitrooxy compound is 3-nitrooxy propanol which is present in an amount from 1 mg to 10 g per kg feed.

11. The feed composition or feed additive of claim 10 , wherein the amount of the at least one antibiotic is present in an amount from 0.5 to 150 mg per kg feed.

12. The feed composition or feed additive of claim 9 which is a form selected from the group consisting of a mineral premix, a vitamin premix, premix including vitamins and minerals, and a bolus.

13. The feed composition or feed additive of claim 9 , wherein the antibiotic is at least one selected from the group consisting of monensin, lasalocid, narasin, maduramycin, semduramycin, salinomycin, avoparcin, actaplanin, and penicillin.

14. The feed composition or feed additive of claim 9 , which further comprises at least one additional active substance selected from the group consisting of diallyl disulfide, garlic oil, allyl isothiocyanate, deoxycholic acid, chenodeoxycholic acid and derivatives thereof.

15. The feed composition or feed additive of claim 9 , wherein the ruminant animal is selected from the group consisting of cattle, goats, sheep, giraffes, American Bison, European bison, yaks, water buffalo, deer, camels, alpacas, llamas, wildebeest, antelope, pronghorn, and nilgai.

Assignees

• Duval Stephane
• Immig Irmgard
• Kindermann Maik
• Weber Gilbert
• Dsm Ip Assets Bv

Inventors

• Duval Stephane
• Immig Irmgard
• Kindermann Maik
• Weber Gilbert

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A61K31/04

  Nitro compounds · CPC title

• A61K31/44

  Non condensed pyridines; Hydrogenated derivatives thereof · CPC title