System and method for electrically ablating tissue of a patient

Patent metadata

Field	Value
Publication number	US-10154876-B2
Application number	US-201715612006-A
Country	US
Kind code	B2
Filing date	Jun 2, 2017
Priority date	Oct 13, 2010
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.

First claim

What is claimed is:

1. A method for ablating tissue of a patient comprising:
placing at least two electrodes within a tissue of the patient;
inputting treatment parameters into an ablation system, the ablation system comprising:
a memory;
a processor coupled to the memory;
a display device connected to the processor, the display device displaying a user interface, the user interface allowing the user to input and change at least one treatment parameter;
a treatment control module stored in the memory and executable by the processor, the treatment control module adapted to:
receive parameters for a target ablation region;
select a number of electrical pulses based on the target ablation region and the positions of the electrodes;
generate an estimated treatment region based on the number of electrical pulses to be applied through the electrodes the generated estimated treatment region displayed on the display prior to a treatment procedure, the estimated treatment region being a non-thermally ablated tissue region, altering the generated estimated treatment region by changing at least one treatment parameter on the user interface; and

delivering treatment to the tissue of the patient.

2. The method of claim 1 , wherein the treatment control module further generates the estimated treatment region based on the number and positions of electrodes.

3. The method of claim 1 , wherein the treatment control module further generates the treatment region based on the positions of the electrodes.

4. The method of claim 1 , wherein the treatment control module displays on the display device a target ablation region superimposed with the generated estimated treatment region.

5. The method of claim 1 , wherein the treatment control module:
generates a plurality of estimated treatment regions based on different numbers of pulses to be applied; and
selects an optimal number of pulses to be applied based on the generated treatment regions.

6. The method of claim 1 , wherein the treatment control module:
generates a plurality of estimated treatment regions based on different numbers of pulses to be applied and different numbers of electrodes; and
selects an optimal number of electrodes to be applied and an optimal number of electrodes based on the generated treatment regions.

7. The method of claim 1 , wherein the treatment control module selects a pulse width based on a target ablation region.

8. The method of claim 1 , wherein the plurality of electrodes includes at least three electrodes (E 1 , E 2 and E 3 ), the system further comprising a pulse generator adapted to deliver, in sequence, at least one pulse to a first pair of electrodes (E 1 -E 2 ), at least one pulse to a second pair of electrodes (E 2 -E 3 ) and at least one other pulse to the first pair of electrodes (E 1 -E 2 ).

9. The method of claim 1 , wherein the plurality of electrodes includes at least three electrodes (E 1 , E 2 and E 3 ), the system further comprising a pulse generator, under the control of the treatment control module, adapted to deliver, in sequence, a set of pulses to a first pair of electrodes (E 1 -E 2 ), a set of pulses to a second pair of electrodes (E 2 -E 3 ), a set of pulses to a third pair of electrodes (E 3 -E 1 ), and then repeat the same sequence of pulse delivery.

10. The method of claim 1 , wherein the treatment control module further generates the estimated treatment region using a Cassini oval equation.

11. The method of claim 10 , wherein treatment control module:
further generates the estimated treatment region using the following Cassini oval equation or its equivalent Cartesian equation:
r 2= a 2 cos(2*theta)+/−sqrt( b 4− a 4 sin 2(2*theta))

wherein a is the distance from the origin to each electrode and b is a constant; and adjusts the constant b based on the number of pulses to be applied.

12. The method of claim 1 , wherein the treatment control module further generates the estimated treatment region according to a predetermined positive relationship between the number of pulses and the size of the ablation region.

13. The method of claim 1 , wherein the treatment control module further generates the estimated treatment region according to a predetermined positive non-linear relationship between the number of pulses and the size of the ablation region.

14. The method of claim 1 , wherein the treatment control module further generates the estimated treatment region according to a tissue conductivity of a tissue region of a patient to be treated.

15. The method of claim 1 , wherein the treatment control module controls a pulse generator to generate two or more sequences of pulses in which an inter-sequence delay is greater than an inter-pulse delay within one sequence.

16. The method of claim 1 , wherein the at least one treatment parameter changed is the depth of the plurality of electrodes.

17. The method of claim 1 , wherein the two electrodes are bipolar electrodes.

18. The method of claim 1 , wherein the two electrodes are monopolar electrodes.

Assignees

• Angiodynamics Inc

Inventors

• Callas Peter
• Warden David
• Pearson Robert M

Classifications

• A61B2018/00577

  Ablation · CPC title

• A61B18/14 Primary

  Probes or electrodes therefor · CPC title

• A61B2018/00613

  Irreversible electroporation · CPC title

• A61B2018/143

  multiple needles · CPC title

• A61B2018/00642

  with feedback, i.e. closed loop control · CPC title