Speed measuring device, speed measuring method, and recording medium

Patent metadata

Field	Value
Publication number	US-10154784-B2
Application number	US-201615176825-A
Country	US
Kind code	B2
Filing date	Jun 8, 2016
Priority date	Jun 8, 2015
Publication date	Dec 18, 2018
Grant date	Dec 18, 2018

Abstract

A speed measuring device with an optical coherence tomography is provided. The speed measuring device includes an optical coherence tomography that obtains an tomographic image of a sample, a motion contrast calculator, a waveform creator that creates a motion contrast wave indicating chronological change of motion contrast, a time lag calculator, a distance calculator that calculates the blood vessel distance in a sample, and a speed calculator that calculates speed of a pulse wave transmitted inside the blood vessel.

First claim

What is claimed is:

1. A speed measuring device comprising:
an optical coherence tomography that divides light, emitted from a light source, into reference light and measuring light to emit the measuring light to irradiation points, which are different from each other, on a surface of a sample including a blood vessel, and to obtain a tomographic image of the sample based on one or more interference signal(s) in which one or more reflected light(s), obtained from the measuring light reflected on the sample, and the reference light are interfering;
a motion contrast calculator that continuously calculates one or more first motion contrast(s) and one or more second motion contrast(s), among the irradiation points, one irradiation point disposed on the blood vessel being defined as a first irradiation point, and another irradiation point disposed on the blood vessel, passes through the first irradiation point, and being different from the first irradiation point being defined as a second irradiation point, and the one or more first motion contrast(s) being one or more motion contrast(s) calculated based on the one or more interference signal(s) at the first irradiation point, and the one or more second motion contrast(s) being the one or more motion contrast(s) calculated based on the one or more interference signal(s) at the second irradiation point;
a waveform creator that creates, based on a calculation result obtained by the motion contrast calculator, a first motion contrast waveform, indicating chronological change in the one or more first motion contrast(s), and a second motion contrast waveform, indicating a chronological change in the one or more second motion contrast(s);
a time lag calculator that calculates time lag that is temporal lag between the first motion contrast waveform and the second motion contrast waveform created by the waveform creator;
a distance calculator that calculates a blood vessel distance along the blood vessel from the first irradiation point to the second irradiation point; and
a speed calculator that calculates, based on the time lag calculated by the time lag calculator and the blood vessel distance calculated by the distance calculator, pulse wave velocity that is velocity of a pulse wave transmitted inside the blood vessel.

2. The speed measuring device according to claim 1 , wherein the one or more motion contrast(s) comprise(s) information indicating a phase difference between two interference signals calculated at unidentical time to each other.

3. The speed measuring device according to claim 1 , wherein the one or more motion contrast(s) comprise(s) information indicating an amplitude difference between two interference signals calculated at unidentical time to each other.

4. The speed measuring device according to claim 1 , wherein the optical coherence tomography scans the measuring light on a surface of the sample along the blood vessel that passes through the first irradiation point and the second irradiation point.

5. The speed measuring device according to claim 1 , wherein the optical coherence tomography performs first scan and second scan on a surface of the sample, in the first scan, the measuring light scanning in a circular manner so as to intersect with the first irradiation point, and in the second scan, the measuring light scanning in a circular manner so as to intersect with the second irradiation point and to include a scan area of the first scan.

6. The speed measuring device according to claim 5 ,
wherein the motion contrast calculator calculates the one or more the first motion contrast(s) and the one or more the second motion contrast(s), among the irradiation points, an irradiation point irradiated by the first scan being defined as the first irradiation point, and an irradiation point irradiated by the second scan being defined as the second irradiation point,
wherein the time lag calculator calculates the time lag based on a difference between time from when a pulse or a pulse wave is detected until when a preset comparison part of the first motion contrast waveform is detected, and time from when a pulse or a pulse wave is detected until when the comparison part of the second motion contrast waveform is detected.

7. The speed measuring device according to claim 1 , further comprising:
an inner radius calculator that calculates an inner radius of the blood vessel based on the one or more interference signal(s) obtained by the optical coherence tomography; and
a blood flow amount calculator that calculates a blood flow amount of the blood vessel based on the inner radius calculated by the inner radius calculator and the pulse wave velocity calculated by the speed calculator.

8. The speed measuring device according to claim 1 further comprising:
an outer and inner radii calculator that calculates an outer radius and an inner radius of the blood vessel based on the one or more interference signal(s) obtained by the optical coherence tomography; and
an elasticity calculator that calculates blood vessel elasticity of the blood vessel based on the outer radius and the inner radius calculated by the outer and inner radii calculator and the pulse wave velocity calculated by the speed calculator.

9. The speed measuring device according to claim 1 , wherein, if the sample is an eye, the positions of the first irradiation point and the second irradiation point are set such that the blood vessel distance is extended by 0.15 mm.

10. A non-transitory tangible recording medium that stores speed measuring program to make a computer function as each means of a speed measuring device that comprises:
an optical coherence tomography that divides light, emitted from a light source, into reference light and measuring light to emit the measuring light to irradiation points, which are different from each other, on a surface of a sample including a blood vessel, and to obtain a tomographic image of the sample based on one or more interference signal(s) in which one or more reflected light(s), obtained from the measuring light reflected on the sample, and the reference light are interfering;
a motion contrast calculator that continuously calculates one or more first motion contrast(s) and one or more second motion contrast(s), among the irradiation points, one irradiation point disposed on the blood vessel being defined as a first irradiation point, and another irradiation point disposed on the blood vessel, passing through the first irradiation point, and being different from the first irradiation point being defined as a second irradiation point, and the one or more first motion contrast(s) being one or more motion contrast(s) calculated based on the one or more interference signal(s) at the first irradiation point, and the one or more second motion contrast(s) being the one or more motion contrast(s) calculated based on the one or more interference signal(s) at the second irradiation point;
a waveform creator that creates, based on a calculation result obtained by the motion contrast calculator, a first motion contrast waveform, indicating chronological change in the one or more first motion contrast(s), and a second motion contrast waveform, indicating a chronological change in the one or more second motion contrast(s);
a time lag calculator that calculates time lag that is temporal lag between the first motion contrast waveform and the second motion contrast waveform created by the waveform creator;
a distance calculator that calculates a blood vessel distance along the blood vessel from the first irradiation point to the second irradiation point; and
a speed calculator that calculates, based on the time lag calculated by the time lag calculator and the blood vess

Assignees

• Tomey Corp

Inventors

• E M Jaillon Franck
• Hara Naoko
• Ohmori Tsutomu

Classifications

• A61B3/102 Primary

  for optical coherence tomography [OCT] · CPC title

• G01P5/18

  by measuring the time taken to traverse a fixed distance · CPC title

• A61B3/1233 Primary

  for measuring blood flow, e.g. at the retina · CPC title

• G01P5/00

  Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft (application of speed-measuring devices for measuring volume of fluid G01F) · CPC title

• G01P3/68

  using optical means, i.e. using infrared, visible, or ultraviolet light (G01P3/80 takes precedence {; by reflection of waves G01S17/58}) · CPC title