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Substituted heterocyclic compounds for treating or preventing viral infections
US10150742B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10150742-B2 |
| Application number | US-201414777109-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 14, 2014 |
| Priority date | Mar 15, 2013 |
| Publication date | Dec 11, 2018 |
| Grant date | Dec 11, 2018 |
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- Title
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- Abstract
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- First independent claim
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Abstract
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Disclosed herein are pyrimidine compounds of formula I and formula II and methods for treating or preventing a viral infection, such as infections caused by dengue virus in a subject, comprising administering to said subject an effective amount of a pyrimidine compound of formula I or formula II.
First claim
Opening claim text (preview).
We claim: 1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of: 2. A method of inhibiting entry of a virus into a host cell comprising contacting the host cell with an effective amount of a compound of claim 1 , wherein the virus is of family Flaviviridae. 3. The method of claim 2 , wherein the virus is dengue virus (DENV). 4. A method of treating or preventing a viral infection in a subject comprising administering to the subject an effective amount of a compound of claim 1 , wherein the viral infection is a result of a virus of family Flaviviridae. 5. The method of claim 4 , wherein the viral infection is a result of dengue virus (DENV). 6. The method of claim 4 , wherein the viral infection is selected from the group consisting of: Dengue fever, Japanese encephalitis, Kyasanur Forest disease, Murray Valley encephalitis, St. Louis encephalitis, Tick-borne encephalitis, West Nile encephalitis, Yellow fever, and Hepatitis C. 7. The compound of claim 1 , wherein the compound is 8. The method of claim 2 , wherein the compound is 9. The method of claim 4 , wherein the compound is
Assignees
Inventors
Classifications
Two nitrogen atoms · CPC title
One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
- C07D239/42Primary
One nitrogen atom (nitro radicals C07D239/30) · CPC title
Benzenesulfonamido-pyrimidines · CPC title
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Frequently asked questions
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- What does patent US10150742B2 cover?
- Disclosed herein are pyrimidine compounds of formula I and formula II and methods for treating or preventing a viral infection, such as infections caused by dengue virus in a subject, comprising administering to said subject an effective amount of a pyrimidine compound of formula I or formula II.
- Who is the assignee on this patent?
- Harvard College, Dana Farber Cancer Inst Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D239/42. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 11 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).