Prevention and treatment of brain diseases and disorders related to abnormal protein aggregation through electromagnetic field treatment

Patent metadata

Field	Value
Publication number	US-10149982-B2
Application number	US-201514976986-A
Country	US
Kind code	B2
Filing date	Dec 21, 2015
Priority date	Mar 11, 2009
Publication date	Dec 11, 2018
Grant date	Dec 11, 2018

Abstract

A method of treating and preventing a neurological disorder, such as Alzheimer's disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a predetermined frequency (preferably ≈300-3,000 MHz) for a predetermined absorption period (preferably greater than ≈3 days). Each individual treatment (comprising exposure to the predetermined frequency for the predetermined absorption period) is continued at a predetermined schedule for a predetermined treatment period. The EMF can have a specific absorption rate up to about 8 W/kg. The methodology enhances cognition in the subject and/or treats/prevents the underlying neurological disorder or a symptom thereof.

First claim

What is claimed is:

1. A method of directly treating or preventing symptoms associated with Alzheimer's disease in a subject, wherein said symptoms are associated with β-amyloid deposit or cognitive ability, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by a digital electromagnetic field, said digital electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days;
reversing or reducing cognitive impairment or β-amyloid aggregation in said subject, decreasing a rate of β-amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days; and
enhancing mitochondrial function within neurons of said subject based on said step of exposing the subject to electromagnetic treatment,
whereby brain temperature of said subject was stable and/or decreased during and/or after exposure of said subject to said electromagnetic treatment.

2. The method of claim 1 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

3. The method of claim 1 , wherein the digital electromagnetic field has a specific absorption rate up to about 8 W/kg.

4. The method of claim 1 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

5. The method of claim 1 , wherein the digital electromagnetic field is pulsed and unmodulated.

6. The method of claim 1 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

7. A method of directly treating or preventing an amyloid-related neurological disorder in a subject thereof, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by an electromagnetic field generated by a digital signal generator said electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency having a range of about 902 MHz to about 928 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days;
reversing or reducing cognitive impairment or amyloid aggregation in said subject, decreasing a rate of amyloid deposition, or enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) day; and
enhancing mitochondrial function within neurons of said subject based on said step of exposing the subject to electromagnetic treatment,
whereby brain temperature of said subject was stable and/or decreased during and/or after exposure of said subject to said electromagnetic treatment.

8. The method of claim 7 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

9. The method of claim 7 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

10. The method of claim 7 , wherein the electromagnetic field is pulsed and unmodulated.

11. The method of claim 7 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

12. A method of directly treating or preventing a neurological disorder in a subject thereof, where the neurological disorder is characterized by abnormal protein aggregation in or around a brain of the subject, the method comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by a digital electromagnetic field, said digital electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days;
reversing or reducing the abnormal protein aggregation in said subject or decreasing a rate of protein deposition based on said step of continuing exposure for greater than about three (3) days; and
enhancing mitochondrial function within neurons of said subject based on said step of exposing the subject to electromagnetic treatment,
whereby brain temperature of said subject was stable and/or decreased during and/or after exposure of said subject to said electromagnetic treatment.

13. The method of claim 12 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

14. The method of claim 12 , wherein the electromagnetic field has a specific absorption rate up to about 8 W/kg.

15. The method of claim 12 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

16. The method of claim 12 , wherein the digital electromagnetic field is pulsed and unmodulated.

17. A method of directly enhancing cognitive function in a subject that is cognitively unimpaired, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by a digital electromagnetic field, said digital electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequency being within an ultra-high frequency (UHF) range of about 300 MHz to about 3,000 MHz;
continuing exposure to the subject for the predetermined absorption period for a predetermined treatment period greater than about three (3) days;
enhancing cognitive performance in said subject based on said step of continuing exposure for greater than about three (3) days; and
enhancing mitochondrial function within neurons of said subject based on said step of exposing the subject to electromagnetic treatment,
whereby brain temperature of said subject was stable and/or decreased during and/or after exposure of said subject to said electromagnetic treatment.

18. The method of claim 17 , wherein the predetermined frequency is within a range of about 902 MHz to about 928 MHz.

19. The method of claim 17 , wherein the digital electromagnetic field has a specific absorption rate up to about 8 NV/kg.

20. The method of claim 17 , wherein the predetermined absorption period is about one hour per treatment session, twice daily.

21. The method of claim 17 , wherein the digital electromagnetic field is pulsed and unmodulated.

22. The method of claim 17 , wherein an enhancement of said cognitive performance in said subject is indicated by an enhancement of working or short-term memory performance of said subject.

23. A method of directly treating or preventing Age-Associated Memory Impairment, comprising:
positioning an electromagnetic field emitting source proximal to the subject;
exposing the subject to electromagnetic treatment by a digital electromagnetic field, said digital electromagnetic field having a predetermined frequency for a predetermined absorption period, said predetermined frequ

Assignees

• Arendash Gary W
• Cao Chuanhai
• Tan Jun
• Univ South Florida
• Us Veterans Affairs

Inventors

• Arendash Gary W
• Cao Chuanhai
• Tan Jun

Classifications

• A61N5/02

  using microwaves · CPC title

• A61N2/006 Primary

  for magnetic stimulation of nerve tissue · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title