Automatic drug injection device with sophisticated drive mechanism

Patent metadata

Field	Value
Publication number	US-10149947-B2
Application number	US-201414782705-A
Country	US
Kind code	B2
Filing date	Apr 8, 2014
Priority date	Apr 10, 2013
Publication date	Dec 11, 2018
Grant date	Dec 11, 2018

Abstract

A drug delivery device for setting and dispensing of a dose of a medicament includes a housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal axial direction. The drug delivery device further includes a drive spindle operably engageable with the piston rod during dose dispensing and a drive member axially displaceable relative to the drive spindle against the action of a spring element during dose setting and being threadedly engaged with the drive spindle to form a spindle gear.

First claim

The invention claimed is:

1. A drug delivery device for setting and dispensing of a dose of a medicament, the device comprises:
an elongated housing;
a cartridge being arranged in the housing, the cartridge containing the medicament and comprising a piston to displace the medicament;
a piston rod configured to be engaged with the piston to displace the piston in a distal direction along a longitudinal axis of the elongate housing;
a drive spindle operably engageable with the piston rod during dose dispensing; and
a drive member comprising a hollow sleeve portion and an axially extending toothed rack portion the hollow sleeve portion being threadedly engaged with the drive spindle, and the drive member being displaceable relative to the drive spindle along the longitudinal axis against a biasing force of a spring element during dose setting and being threadedly engaged with the drive spindle to form a spindle gear,
wherein the drive member is displaceable in a proximal direction along the longitudinal axis against the biasing force of the spring element for setting the dose during the dose setting, and
wherein the drive member is displaceable in the distal direction under the biasing force of the spring element for dispensing the dose during the dose dispensing, displacement of the drive member in the distal direction being configured to rotate the drive spindle in dose decrementing direction during the dose dispensing.

2. The drug delivery device according to claim 1 , further comprising a dose setting member rotatable mounted to a sidewall of the housing.

3. The drug delivery device according to claim 2 , wherein the rack portion of the drive member is engaged with a pinion of a gear wheel operably engaged with the dose setting member.

4. A drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the drive mechanism comprising:
an elongated housing;
a piston rod configured to be engaged with a piston of a cartridge to displace the piston in a distal direction along a longitudinal axis of the housing;
a drive spindle operably engageable with the piston rod during dose dispensing; and
a drive member comprising a hollow sleeve portion and an axially extending toothed rack portion, the hollow sleeve portion being threadely engaged with the drive spindle, and the drive member being displaceable relative to the drive spindle along the longitudinal axis against a biasing force of a spring clement during dose setting and being threadedly engaged with the drive spindle to form a spindle gear,
wherein the drive member is displaceable in a proximal direction along the longitudinal axis against the biasing force of the spring element for setting the dose during the dose setting, and
wherein the drive member is displaceable in the distal direction under the biasing force of the spring element for dispensing the dose during the dose dispensing, displacement of the drive member in the distal direction being configured to rotate the drive spindle in a dose decrementing direction during the dose dispensing.

5. The drive mechanism according to claim 4 , further comprising a dose setting member rotatably mounted to a sidewall of the housing.

6. The drive mechanism according to claim 5 , wherein the dose setting member is rotatably engaged with a first dose indicating wheel and with a second dose indicating wheel to display at least first and second digits, respectively, of a number in a dose indicating window of the housing.

7. The drive mechanism according to claim 5 , wherein the rack portion of the drive member is engaged with a pinion of a gear wheel operably engaged with the dose setting member.

8. The drive mechanism according to claim 1 , wherein the drive member is axially slidably disposed in the housing.

9. The drive mechanism according to claim 1 , wherein the drive member is axially displaceable relative to the housing between a distal stop and a proximal stop.

10. The drive mechanism according to claim 1 , wherein the spring element comprises a compression spring extending around the drive spindle.

11. The drive mechanism according to claim 1 , wherein the spring element axially extends between the drive member and the drive spindle.

12. The drive mechanism according to claim 1 , wherein the drive spindle comprises a toothed rim rotatably engaged with a ratchet member.

13. The drive mechanism according to claim 12 , wherein the ratchet member comprises an arc-shaped latch element variably stressable in a radial direction such that the latch element is selectively engageable and disengageable with the toothed rim of the drive spindle.

14. The drive mechanism according to claim 12 , further comprising a pinion fixed to a distal end of the drive spindle and geared with a drive sleeve rotatably supported in the housing.

15. The drive mechanism according to claim 14 , wherein the drive sleeve is axially displaceable between a distal stop position and a proximal stop position, the drive sleeve being configured to be rotatably engaged with the piston rod in the distal stop position and to be rotatably disengaged from the piston rod in the proximal stop position.

16. The drive mechanism according to claim 14 , further comprising a dose dispensing button displaceable along the longitudinal axis and being located at a proximal end of the housing, the button being configured to engage with the ratchet member in a dose setting mode and with the drive sleeve in a dose dispensing mode.

17. A drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the drive mechanism comprising:
an elongated housing;
a piston rod configured to be engaged with a piston of a cartridge to displace the piston in a distal direction along a longitudinal axis of the housing;
a drive spindle comprising a toothed rim rotatably engaged with a ratchet member and operably engageable with the piston rod during dose dispensing;
a pinion fixed to a distal end of the drive spindle and geared with a drive sleeve rotatably supported in the housing;
a dose dispensing button displaceable along the longitudinal axis and being located at a proximal end of the housing, the button being configured to engage with the ratchet member in a dose setting mode and with the drive sleeve in a dose dispensing mode; and
a drive member displaceable relative to the drive spindle along the longitudinal axis against a biasing force of a spring element during dose setting and being threadedly engaged with the drive spindle to form a spindle gear.

18. The drive mechanism according to claim 17 , farther comprising a dose setting member rotatably mounted to a sidewall of the housing.

19. The drive mechanism according to claim 18 , wherein the dose setting member is rotatably engaged with a first dose indicating wheel and with a second dose indicating wheel to display at least first and second digits, respectively, of a number in a dose indicating window of the housing.

20. The drive mechanism according to claim 17 , wherein the drive member is axially slidably disposed in the housing.

Assignees

• Sanofi Sa

Inventors

• Bayer Stefan
• Berning Daniel
• Blank Philippe
• Pelzer Wolfgang
• Wilden Björn

Classifications

• A61M5/31558

  using scaling up or down transmissions, e.g. gearbox · CPC title

• A61M5/31591

  Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means · CPC title

• A61M5/31593

  Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir · CPC title

• A61M2005/3154

  limiting maximum permissible dose · CPC title

• A61M2005/202

  cocking means, e.g. to bias the main drive spring of an injector · CPC title