Implant with controlled porosity made of a hybrid material

Patent metadata

Field	Value
Publication number	US-10149920-B2
Application number	US-201414894943-A
Country	US
Kind code	B2
Filing date	Jun 3, 2014
Priority date	Jun 3, 2013
Publication date	Dec 11, 2018
Grant date	Dec 11, 2018

Abstract

The disclosure relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising this material, to a method for producing such an implant, and to a method for producing a hybrid material. The implant material comprises a hybrid material comprising: a bioactive glass M based on SiO 2 and CaO, optionally containing P 2 O 5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in a solvent and chosen from among bioresorbable polysaccharides. The implant material has applications in the medical field.

First claim

The invention claimed is:

1. A method for manufacturing an implant made of a hybrid material for filling bone defects, for bone regeneration, and for bone tissue engineering, comprising the following successive steps:
a) selecting a bioactive glass M based on SiO 2 and CaO, optionally containing P 2 O 5 and/or optionally doped with strontium,
b) selecting a biodegradable polymer P that is soluble in at least one solvent S1 and insoluble in at least one solvent S different from the solvent S1,
c) selecting microspheres of a porogenic agent A having diameters and sizes corresponding to the desired diameters and sizes of the pores in the material constituting the implant to be manufactured, this porogenic agent A being:
a polymer insoluble in the at least one solvent S1 and soluble in the at least one solvent S,
the at least one solvent S in which the material of the biodegradable polymer P is insoluble and the at least one solvent S in which the material of the porogenic agent A is soluble being identical,

d) introducing the microspheres of the porogenic agent A into a mold having the required shape and size for the implant, these microspheres forming a compact stack corresponding to the shape and size of the pores to be obtained in the implant material, and representing at least 60 vol % relative to the total volume of the mixture of porogenic agent A-biodegradable polymer P-alkoxide precursors of the bioactive glass M,
e) adding the biodegradable polymer P to the alkoxide precursors of at least SiO 2 and CaO of the bioactive glass M, wherein the alkoxide precursor of CaO is calcium ethoxide,
f) putting the mixture obtained in step e) into the mold,
g) gelling the mixture contained in the mold after step f),
h) removing the mixture obtained in step g) from the mold,
i) removing the microspheres of porogenic agent A by washing with the solvent S, and
j) crosslinking of the mixture obtained in step i).

2. The method as claimed in claim 1 , wherein step e) and/or step f) are carried out before step d).

3. The method as claimed in claim 1 , wherein steps d) and e) and f) are carried out simultaneously.

4. The method as claimed in claim 1 , wherein the biodegradable polymer P is selected from:
biodegradable polymers that are soluble in at least one solvent S1 and insoluble in at least one solvent S selected from:
bioabsorbable polysaccharides,
bioabsorbable polyesters,
biodegradable synthetic polymers,
proteins,
wherein the material of the porogenic agent A is selected from biodegradable polymers that are insoluble in the at least one solvent S1 and soluble in the at least one solvent S, and
the material of the porogenic agent A being different from the biodegradable polymer P.

5. The method as claimed in claim 1 , wherein the weight ratio biodegradable polymer P/bioactive glass M is between 20/80 and 80/20, inclusive.

6. The method as claimed in claim 1 , wherein the bioactive glass M is a glass based on SiO 2 and CaO, the biodegradable polymer P is gelatin, the material of the microspheres of porogenic agent A is polymethyl methacrylate and the solvent S is acetone.

7. The method as claimed in claim 1 , further comprising, in step f), a step of introducing a coupling agent.

8. The method as claimed in claim 1 , comprising after step d), and before step e), a step of enlarging the interconnections (4), by infiltration of a solvent S of the material of the porogenic agent A, into the stack of the microspheres of porogenic agent A and/or by heating this stack.

9. The method as claimed in claim 1 wherein, in step d), the microspheres of the porogenic agent A represent at least 70 vol % relative to the total volume of the mixture of porogenic agent A-biodegradable polymer P-alkoxide precursors of the bioactive glass M.

10. The method as claimed in claim 4 wherein:
the bioabsorbable polysaccharides are selected from the group consisting of dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, and pectin,
the bioabsorbable polyesters are polyvinyl alcohol or poly(lactic acid),
the biodegradable synthetic polymers are a polyethylene glycol, or poly(caprolactone),
the proteins are gelatin or collagen.

11. The method as claimed in claim 4 wherein the material of the porogenic agent A is selected from the group consisting of C1 to C4 polyalkyl methacrylates, polymethyl methacrylate or polybutyl methacrylate, polyurethane, polyglycolic acid, copolymers of lactic-coglycolic acids, polycaprolactone, polypropylene fumarate, paraffin and naphthalene, and acrylonitrile butadiene styrene (ABS).

12. The method as claimed in claim 7 wherein the coupling agent is an organoalkoxysilane compound.

13. The method as claimed in claim 12 wherein the organoalkoxysilane compound is 3-glycidoxypropyltrimethoxysilane (GPMS) or 3-glycidoxypropyltriethoxysilane (GPTES).

Assignees

• Univ Blaise Pascal Clermont Ferrand Ii
• Centre Nat Rech Scient
• Univ Clermont Auvergne

Inventors

• Lao Jonathan Claude Alexandre
• Lacroix Joséphine
• Jallot Edouard Daniel Albert
• Dieudonne Xavier

Classifications

• A61L27/16 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L27/446

  with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46 · CPC title

• A61L27/24

  Collagen · CPC title

• A61L2300/412

  Tissue-regenerating or healing or proliferative agents · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title