Vaccine for Use in Protecting a Pig Against Porcine Endemic Diarrhea Virus
US-2017304431-A1 · Oct 26, 2017 · US
Vaccine for use in protecting a pig against porcine epidemic diarrhea virus
US10143738B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10143738-B2 |
| Application number | US-201515509999-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 11, 2015 |
| Priority date | Sep 12, 2014 |
| Publication date | Dec 4, 2018 |
| Grant date | Dec 4, 2018 |
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Abstract
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The invention pertains to a vaccine for use in protecting a pig against an infection with porcine epidemic diarrhea virus (PEDV), the vaccine comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, by administration of a dose of the antigen corresponding to at least 3.0E6 TCID 50 killed whole PEDV. The invention also pertains to a method of protecting a pig against an infection with porcine epidemic diarrhea virus.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method to protect a pig against an infection with porcine epidemic diarrhea virus (PEDV) comprising administering to the pig a vaccine comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, and the antigen is administered at a dose corresponding to at least 3.0E6 TCID 50 killed whole PEDV. 2. The method of claim 1 , wherein the dose of the antigen corresponds to at least 1.5E7 TCID 50 killed whole PEDV. 3. The method of claim 1 , wherein the total amount of the oil is less than 40% v/v. 4. The method of claim 1 , wherein the oil is emulsified in an hydrophilic solvent. 5. The method of claim 1 , wherein the vaccine in addition to the non-metabolizable oil comprises vitamin E acetate. 6. The method of claim 1 , wherein the antigen contains a polypeptide that corresponds to the C terminal two-third of the S1 domain of the spike protein of PEDV. 7. The method of claim 6 , wherein the polypeptide corresponds to the S1 domain of the spike protein of PEDV. 8. The method of claim 7 , wherein the polypeptide corresponds to the spike protein of PEDV. 9. The method of claim 1 , wherein the antigen is killed whole PEDV. 10. A vaccine to protect a pig against an infection with porcine epidemic diarrhea virus (PEDV) comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, and the antigen is present in a concentration corresponding to at least 1.5E6 TCID 50 killed whole PEDV per ml.
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Classifications
Veterinary vaccine · CPC title
characterised by the dose, timing or administration schedule · CPC title
Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) · CPC title
Proteins; Peptides · CPC title
Bacterial toxins · CPC title
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- What does patent US10143738B2 cover?
- The invention pertains to a vaccine for use in protecting a pig against an infection with porcine epidemic diarrhea virus (PEDV), the vaccine comprising non-live PEDV antigen and a non-metabolizable oil containing adjuvant, wherein the total amount of oil in the vaccine is less than 50% v/v, by administration of a dose of the antigen corresponding to at least 3.0E6 TCID 50 killed whole PEDV. T…
- Who is the assignee on this patent?
- Intervet Inc, Univ Utrecht Holding Bv
- What technology area does this patent fall under?
- Primary CPC classification A61K39/12. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Dec 04 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).