Systems and methods for treating cancer and/or augmenting organ function

Patent metadata

Field	Value
Publication number	US-10143419-B2
Application number	US-201414895744-A
Country	US
Kind code	B2
Filing date	Oct 14, 2014
Priority date	Oct 15, 2013
Publication date	Dec 4, 2018
Grant date	Dec 4, 2018

Abstract

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

First claim

What is claimed is:

1. A system, comprising:
one of a catheter and a guidewire dimensioned for insertion into a lumen comprising a wall, the lumen being in fluid communication with at least one of a target organ and a tumor;
one of the catheter and the guidewire comprising a distal tip configured to interface with the wall of the lumen, the distal tip configured to deliver at least one of an energy and a substance to at least one of: one or more nerves coupled to the target organ; and the wall of the lumen;
one or more sensing elements coupled with the distal tip; and
a controller coupled to one of the catheter and the guidewire, the controller being configured:
to utilize at least one of the one or more sensing elements coupled with the distal tip to acquire positional information related to placement of the distal tip relative to the target organ;
to apply a stimulus to the target organ while monitoring neural traffic along the wall of the lumen utilizing at least one of the one or more sensing elements;
to adjust placement of the distal tip relative to the target organ based on the monitored neural traffic along the wall of the lumen; and
to control delivery of at least one of the energy and the substance to the target organ to alter one or more neural structures coupled to the tumor;

wherein the controller is configured to adjust the placement of the distal tip relative to the target organ based on the monitored neural traffic along the wall of the lumen to a desired location relative to the target organ by monitoring the neural traffic along the wall of the lumen in response to the applied stimulus until the monitored neural traffic registers a desired response to the applied stimulus.

2. The system in accordance with claim 1 , wherein the distal tip comprises a balloon, a basket, a deployable helix, a deployable microneedle, or a combination thereof for interfacing with the wall of the lumen.

3. The system in accordance with claim 1 , wherein the energy is thermal energy, radio frequency current, microwave current, ultrasound, radiation, cryotherapy, or combinations thereof.

4. The system in accordance with claim 1 , wherein the substance is a medicament, a denervating agent, an sympathetic nerve specific denervating agent, a parasympathetic nerve specific denervating agent, a neuroblocking agent, a highly specific neuroblocking agent, or a combination thereof.

5. The system in accordance with claim 1 , wherein the substance is ethanol, phenol, botulinum toxin, a derivative, or a combination thereof.

6. The system in accordance with claim 1 , wherein the system is configured to direct energy through one or more energy delivery elements coupled to the distal tip based upon information collected by the one or more sensing elements.

7. The system in accordance with claim 1 , wherein the one or more sensing elements are configured to at least one of monitor and determine one or more signals relating to regions of abnormal electrophysiological activity, determine a direction of nerve traffic along nerves within a first threshold distance of the lumen, determine sympathetic neural activity in the vicinity of the lumen, determine a type of nerves situated within a second threshold distance of the sensing element, determine an effectiveness of the energy and/or substance delivery, determine a response of nerve traffic to a stress test performed on the body or the organ, or combinations thereof.

8. The system in accordance with claim 1 , further comprising a substance eluting element coupled to the distal tip, the substance eluting element configured to deliver a substance, a medicament, a denervating substance, or combinations thereof into the target organ, into a perivascular site surrounding the wall of the lumen, into an adventitia of the lumen, into a microenvironment of the tumor, into the lumen, or a combination thereof.

9. The system in accordance with claim 1 , wherein the distal tip has a characteristic diameter of one of less than 1 mm, less than 0.75 mm, less than 0.5 mm, and less than 0.3 mm so as to access the lumen one of within a threshold distance of a site and within the site within the target organ.

10. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises at least one of providing a neural block to one or more regions of the one or more neural structures and ablating one or more regions of the one or more neural structures.

11. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises modulating neural communication between the tumor and the one or more neural structures coupled to the target organ.

12. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises decoupling a neurological connection between the tumor and the one or more neural structures.

13. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises inducing at least one of necrosis and apoptosis within neural tissues within the one or more neural structures coupled with the tumor.

14. The system in accordance with claim 1 wherein controlling delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises delivering at least one of the energy and the substance to one or more neurological structures in one or more vascular supply lumens of the target organ.

15. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises selectively treating one or more regions of the target organ while maintaining regular function of one or more other regions of the target organ.

16. The system in accordance with claim 1 wherein controlling the delivery of at least one of the energy and the substance to the target organ to alter the one or more neural structures coupled to the tumor comprises applying at least one of the energy and the substance selectively to one or more sympathetic nerves and one or more parasympathetic nerves to adjust a balance in activity between the one or more sympathetic nerves and the one or more parasympathetic nerves.

17. The system in accordance with claim 1 wherein the controller is further configured:
to utilize at least one of the one or more sensing elements to monitor neural traffic along the wall of the lumen subsequent to delivery of at least one of the energy and the substance to the target organ; and
to determine a change in neural traffic activity utilizing the monitored neural traffic to assess if a treatment was successful.

18. The system in accordance with claim 17 , wherein determining the change in the neural activity comprises at least one of:
determining a change in activity level of the one or more neural structures coupled to the tumor;
determining a shift in a polarity of signals of the one or more neural structures coupled to the tumor; and
determining a drop off in periodic behavior of s

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Schwartz Robert S

Classifications

• A61B5/4884

  inducing physiological or psychological stress, e.g. applications for stress testing · CPC title

• A61B2018/1861

  with an instrument inserted into a body lumen or cavity, e.g. a catheter · CPC title

• A61F2007/126

  for invasive application, e.g. for introducing into blood vessels · CPC title

• A61B5/4839 Primary

  combined with drug delivery · CPC title

• A61B18/1492 Primary

  having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence) · CPC title