System and method for sleep session management based on slow wave sleep activity in a subject

Patent metadata

Field	Value
Publication number	US-10137276-B2
Application number	US-201414784782-A
Country	US
Kind code	B2
Filing date	Apr 20, 2014
Priority date	Apr 19, 2013
Publication date	Nov 27, 2018
Grant date	Nov 27, 2018

Abstract

The present disclosure pertains to a system and method for managing a sleep session of a subject. Managing the sleep session is based on slow wave activity in the subject during the sleep session. Slow wave activity is related to sleep pressure. Sleep pressure dissipates and/or decreases as the subject sleeps. The dissipation dynamics depend on a given subject. The manner in which dissipation occurs regulates the length of the given sleep session and is linked to the temporal dynamics of slow wave activity. The system is configured to determine a metric indicating sleep pressure dissipation and, responsive to the determined sleep pressure dissipation metric indicating that sleep pressure dissipation has reached a dissipation threshold level during the sleep session, wake the subject.

First claim

The invention claimed is:

1. A system configured to manage a sleep session of a subject, the system comprising:
one or more sensory stimulators configured to provide sensory stimuli to the subject;
one or more sensors configured to generate output signals conveying information related to a current sleep stage of the subject during the sleep session; and
one or more processors configured by machine-readable instructions to:
determine a dissipation threshold level for triggering a sensory waking stimulus;
obtain, during the sleep session, the output signals from the one or more sensors, at least some of the output signals being related to slow wave activity in the subject;
monitor, during the sleep session, the slow wave activity based on the output signals;
determine, based on the monitoring of the slow wave activity, a rate of change in the slow wave activity over time with respect to the sleep session;
determine a sleep pressure dissipation level of the subject based on the rate of change in the slow wave activity, the sleep pressure dissipation level being a metric indicating a level of dissipation with respect to sleep pressure of the subject, the sleep pressure indicating the subject's remaining need for sleep; and
responsive to the sleep pressure dissipation level breaching the dissipation threshold level, control the one or more sensory stimulators to generate the sensory waking stimulus to cause the subject to wake from the sleep session.

2. The system of claim 1 , wherein the one or more processors are configured to determine the dissipation threshold level based on information from one or more previous sleep sessions of the subject.

3. The system of claim 1 , further comprising a user interface configured to receive information related to a sleep session duration target for the subject;
wherein the one or more sensory stimulators are configured to provide sensory stimulation separate from the sensory waking stimulus to the subject during the sleep session to adjust the slow wave activity in the subject; and
wherein the one or more processors are configured to control the one or more sensory stimulators to adjust the slow wave activity in the subject such that a sleep session duration meets the sleep session duration target, the one or more processors configured to control the one or more sensory stimulators based on the sleep session duration target, the determined sleep pressure dissipation level, and the dissipation threshold level.

4. The system of claim 3 , wherein the one or more processors are configured to provide the sensory stimulation separate from the sensory waking stimulus to the subject during the sleep session to increase and/or decrease the slow wave activity in the subject such that control ling the one or more sensory stimulators to increase the slow wave activity in the subject results in faster sleep pressure dissipation and an increase in the sleep pressure dissipation level, and controlling the one or more sensory stimulators to decrease the slow wave activity in the subject results in slower sleep pressure dissipation and a decrease in the sleep pressure dissipation level.

5. The system of claim 3 , wherein the one or more processors are configured to control the one or more sensory stimulators to provide the sensory stimulation separate from the sensory waking stimulus to the subject to adjust the slow wave activity in the subject while the subject is asleep during the sleep session and/or while the subject is awake before the sleep session such that the sleep session duration meets the sleep session duration target for the sleep session.

6. A method for managing a sleep session of a subject with a management system, the system comprising one or more sensory stimulators, one or more sensors, and one or more processors configured by machine-readable instructions, the method comprising:
generating output signals conveying information related to a current sleep stage of the subject during the sleep session with the one or more sensors;
determining, with the one or more processors, a dissipation threshold level for triggering a sensory waking stimulus;
obtaining, with the one or more processors, during the sleep session, the output signals from the one or more sensors, at least some of the output signals being related to slow wave activity in the subject;
monitoring, with the one or more processors, during the sleep session, the slow wave activity based on the output signals;
determining, with the one or more processors, based on the monitoring of the slow wave activity, a rate of change in the slow wave activity over time with respect to the sleep session;
determining, with the one or more processors, a sleep pressure dissipation level of the subject based on the rate of change in the slow wave activity, the sleep pressure dissipation level being a metric indicating a level of dissipation with respect to sleep pressure of the subject, the sleep pressure indicating the subject's remaining need for sleep; and
responsive to the sleep pressure dissipation level breaching the dissipation threshold level, controlling, with the one or more processors, the one or more sensory stimulators to generate the sensory waking stimulus to cause the subject to wake from the sleep session.

7. The method of claim 6 , further comprising determining, with the one or more processors, the dissipation threshold level based on information from one or more previous sleep sessions of the subject.

8. The method of claim 6 , further comprising receiving information related to a sleep session duration target for the subject via a user interface;
providing sensory stimulation separate from the sensory waking stimulus to the subject with the one or more sensory stimulators during the sleep session to adjust the slow wave activity in the subject; and
controlling, with the one or more processors, the one or more sensory stimulators to adjust the slow wave activity in the subject such that a sleep session duration meets the sleep session duration target, the controlling based on the sleep session duration target, the determined sleep pressure dissipation level, and the dissipation threshold level.

9. The method of claim 8 , wherein controlling, with the one or more processors, the one or more sensory stimulators to provide the sensory stimulation separate from the sensory waking stimulus to the subject during the sleep session to adjust the slow wave activity in the subject comprises controlling the one or more sensory stimulators to increase and/or decrease the slow wave activity in the subject such that controlling the one or more sensory stimulators to increase the slow wave activity in the subject results in faster sleep pressure dissipation and an increase in the sleep pressure dissipation level, and controlling the one or more sensory stimulators to decrease the slow wave activity in the subject results in slower sleep pressure dissipation and a decrease in the sleep pressure dissipation level.

10. The method of claim 8 , further comprising controlling, with the one or more processors, the one or more sensory stimulators to provide the sensory stimulation separate from the sensory waking stimulus to the subject to adjust the slow wave activity in the subject while the subject is asleep during the sleep session and/or while the subject is awake before the sleep session such that the sleep session duration meets the sleep session duration target for the sleep session.

11. A system configured to manage a sleep session of a subject, the system comprising:
means for providing sensory stimuli to the subject;
means for generating output signals conveying information related to a current sle

Assignees

• Koninklijke Philips Nv
• Wisconsin Alumni Res Found

Inventors

• Garcia Molina Gary Nelson
• Tononi Giulio
• Pastoor Sander Theodoor
• Pfundtner Stefan
• Riedner Brady Alexander
• Bellesi Michele

Classifications

• A61M2230/42

  Rate · CPC title

• A61M2021/0016

  by the smell sense · CPC title

• A61N1/0456

  Specially adapted for transcutaneous electrical nerve stimulation [TENS] · CPC title

• A61M2230/10

  Electroencephalographic signals · CPC title

• A61N1/36025

  for treating a mental or cerebral condition · CPC title