Curcuminoid-based compound/stevioside-containing complex for the prevention and treatment of an influenza virus infection

Patent metadata

Field	Value
Publication number	US-10136663-B2
Application number	US-201214126106-A
Country	US
Kind code	B2
Filing date	Jun 13, 2012
Priority date	Jun 13, 2011
Publication date	Nov 27, 2018
Grant date	Nov 27, 2018

Abstract

The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

First claim

What is claimed is:

1. A method of treating a H9N2 influenza virus infection, comprising administering to an individual in need thereof a composition comprising therapeutically effective amounts of the compound of formula (I) and stevioside:

wherein, R 1 and R 2 are each independently hydrogen, hydroxy, or C 1 -C 10 alkoxy;
n is an integer of 1 to 5; and
m is an integer of 1 to 5.

2. The method of claim 1 , wherein the composition is orally administered.

3. The method of claim 1 , wherein the compound of formula (I) is obtained from turmeric extract, and the stevioside is obtained from Stevia rebaudiana Bertoni.

4. The method of claim 1 , wherein the composition is formulated as at least one selected from a tablet, a pellet, powder, a granule, a capsule, a suspension, a liquid, an emulsion, a syrup, a sterilized aqueous solution, a non-aqueous solvent, a lyophilized preparation, and a suppository.

5. The method of claim 1 , wherein the composition is a food.

Assignees

• Lee Woo Song
• Ryu Young Bae
• Kim Young Min
• Park Su Jin
• Rho Mun Chual
• Jeong Hyung Jae
• Kwon Hyung Jun
• Korea Res Inst Bioscience & Biotechnology

Inventors

• Lee Woo-Song
• Ryu Young-Bae
• Kim Young-Min
• Park Su-Jin
• Rho Mun-Chual
• Jeong Hyung-Jae
• Kwon Hyung-Jun

Classifications

• A23K50/75

  for poultry · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K31/704 Primary

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61K31/12

  Ketones · CPC title