Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US-9533954-B2 · Jan 3, 2017 · US
Substituted tricyclic compounds as FGFR inhibitors
US10131667B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10131667-B2 |
| Application number | US-201715408768-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 18, 2017 |
| Priority date | Jun 13, 2012 |
| Publication date | Nov 20, 2018 |
| Grant date | Nov 20, 2018 |
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- Title
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Abstract
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The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating cancer in a patient comprising administering to said patient a therapeutically effective amount of 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one, or a pharmaceutically acceptable salt thereof, wherein said cancer is selected from bladder cancer, breast cancer, endometrial cancer, gastric cancer, lung cancer, non-small cell lung cancer, adenocarcinoma, multiple myeloma, myeloproliferative neoplasms (MPN), esophageal cancer, head and neck cancer, glioblastoma, ovarian cancer, cervical cancer and liver cancer. 2. The method of claim 1 , wherein the cancer is bladder cancer. 3. The method of claim 1 , wherein the cancer is breast cancer. 4. The method of claim 1 , wherein the cancer is endometrial cancer. 5. The method of claim 1 , wherein the cancer is gastric cancer. 6. The method of claim 1 , wherein the cancer is lung cancer. 7. The method of claim 1 , wherein the cancer is non-small cell lung cancer. 8. The method of claim 1 , wherein the cancer is adenocarcinoma. 9. The method of claim 1 , wherein the cancer is myeloproliferative neoplasms (MPN). 10. The method of claim 1 , wherein the cancer is multiple myeloma. 11. The method of claim 1 , wherein the cancer is esophageal cancer. 12. The method of claim 1 , wherein the cancer is head and neck cancer. 13. The method of claim 1 , wherein the cancer is glioblastoma. 14. The method of claim 1 , wherein the cancer is ovarian cancer. 15. The method of claim 1 , wherein the cancer is cervical cancer. 16. The method of claim 1 , wherein the cancer is liver cancer.
Assignees
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Classifications
Spiro-condensed systems · CPC title
- C07D471/14Primary
Ortho-condensed systems · CPC title
Ortho-condensed systems · CPC title
in which the condensed systems contains four or more hetero rings · CPC title
in which the condensed system contains four or more hetero rings · CPC title
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Frequently asked questions
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- What does patent US10131667B2 cover?
- The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
- Who is the assignee on this patent?
- Incyte Corp, Incyte Holdings Corp
- What technology area does this patent fall under?
- Primary CPC classification C07D471/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).