Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
US-9764019-B2 · Sep 19, 2017 · US
Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
US10130695B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10130695-B2 |
| Application number | US-201715680629-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 18, 2017 |
| Priority date | Jul 9, 2013 |
| Publication date | Nov 20, 2018 |
| Grant date | Nov 20, 2018 |
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- Title
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Abstract
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Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions results in any or all of: induction of immune tolerance; strengthening of the gut mucosal barrier integrity; reduction of inflammation; and amelioration of a disease state caused by inflammation, an autoimmune reaction or an infectious agent.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition that induces proliferation and/or accumulation of regulatory T cells, the composition comprising: (a) one or more short-chain fatty acid or short-chain fatty acid derivative; and (b) one or more protein antigens purified from bacteria belonging to Clostridium Cluster IV, Clostridium Cluster XIVa, or Clostridium Cluster XVIII. 2. The composition of claim 1 , wherein (a) is selected from the group consisting of butyrate, isobutyrate, proprionate, acetate, tributyrin, pivaloyloxymethyl butyrate, and monoacetone glucose 3-butyrate. 3. The composition of claim 1 , wherein (a) is butyrate. 4. The composition of claim 1 , wherein (a) is a mixture of salts of butyrate, isobutyrate, propionate, and acetate. 5. The composition of claim 1 , further comprising a pH sensitive composition comprising an enteric polymer. 6. A pharmaceutical composition comprising the composition according to claim 1 and a pharmaceutically acceptable component. 7. A method for inducing proliferation and/or accumulation of regulatory T cells in an individual in need thereof, the method comprising administering, to the individual, the composition of claim 1 . 8. A method of treating, aiding in treating, reducing the severity of, or preventing at least one disease selected from an autoimmune disease, an inflammatory disease, an allergic disease, and an infectious disease in an individual in need thereof, the method comprising administering the composition of claim 1 to the individual.
Assignees
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Classifications
Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Drugs for immunological or allergic disorders · CPC title
Antibacterial agents · CPC title
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
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- What does patent US10130695B2 cover?
- Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated i…
- Who is the assignee on this patent?
- Vedanta Biosciences Inc, Riken
- What technology area does this patent fall under?
- Primary CPC classification A61K39/0008. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).