Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes
US-12173314-B2 · Dec 24, 2024 · US
Compositions and methods for the treatment of orthopedic disease or injury
US10130687B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10130687-B2 |
| Application number | US-201213976617-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 5, 2012 |
| Priority date | Jan 5, 2011 |
| Publication date | Nov 20, 2018 |
| Grant date | Nov 20, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for promoting cartilage formation in a subject in need thereof, comprising administering to said subject a composition comprising a purified matrilin protein, thereby promoting cartilage formation in said subject, wherein said composition is administered directly into or onto the cartilage of an articulating joint or osteochondral tissue, and wherein said matrilin protein comprises the amino acid sequence of SEQ ID NO: 1, amino acids 29-440 of SEQ ID NO: 1, or SEQ ID NO: 4. 2. The method of claim 1 , wherein said composition further comprises a matrilin-1 protein. 3. The method of claim 1 , wherein said articulating joint comprises a knee, hip, elbow, or shoulder. 4. The method of claim 1 , wherein said osteochondral tissue comprises a vertebra. 5. The method of claim 1 , wherein said composition is administered by injection. 6. The method of claim 1 , wherein said composition is formulated as a biologic glue or cement.
Assignees
Inventors
Classifications
for joint disorders, e.g. arthritis, arthrosis · CPC title
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG] · CPC title
from animals; from humans {(enzyme inhibitors A61K38/005)} · CPC title
characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered · CPC title
- A61K38/39Primary
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10130687B2 cover?
- Methods for reducing the severity of an arthritic condition or repairing an osteochondral defect are carried out by administering to a subject compositions comprising a member of the matrilin family of proteins, e.g., a matrilin protein, fragment thereof, or nucleic acid encoding the protein or fragment.
- Who is the assignee on this patent?
- Chen Qian, Jayasuriya Chathuraka T, Rhode Island Hospital
- What technology area does this patent fall under?
- Primary CPC classification A61K38/39. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).