Compositions and devices

Patent metadata

Field	Value
Publication number	US-10130597-B2
Application number	US-86662409-A
Country	US
Kind code	B2
Filing date	Feb 6, 2009
Priority date	Feb 8, 2008
Publication date	Nov 20, 2018
Grant date	Nov 20, 2018

Abstract

The present invention provides oral instruments comprising a basic amino acid, to compositions for making such instruments, and to methods of making and using such instruments.

First claim

The invention claimed is:

1. An instrument, wherein at least a portion of the instrument is coated with a composition comprising a scaffold having pores, and a basic amino acid residing within said pores, wherein said pores are on average from about 10 μm to about 500 μm in diameter, and wherein the instrument is a toothbrush comprising a head having bristles attached thereto.

2. The instrument of claim 1 wherein the basic amino acid is selected from arginine, lysine, citrullene, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, salts thereof and combinations thereof.

3. The instrument of claim 1 wherein the basic amino acid has the L-configuration.

4. The instrument of claim 1 wherein the basic amino acid is arginine.

5. The instrument of claim 3 wherein the basic amino acid is L-arginine.

6. The instrument of claim 1 wherein said basic amino acid is in salt form.

7. The instrument of claim 6 , wherein the salt form of said basic amino acid is arginine phosphate.

8. The instrument of claim 6 , wherein the salt form of said basic amino acid is arginine hydrochloride.

9. The instrument of claim 1 , wherein the composition further comprises an anionic polymer.

10. The instrument of claim 6 , wherein the salt from of said basic amino acid is arginine bicarbonate.

11. The instrument of claim 1 wherein the bristles are coated.

12. The instrument of claim 1 wherein the head is coated.

13. A method to: (1) reduce or inhibit formation of dental caries, (ii) reduce repair or inhibit pre-caries lesions of the enamel, e.g., as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM), (iii) reduce or inhibit demineralization and promote remineralization of the teeth, (iv) reduce hypersensitivity of the teeth, (v) reduce or inhibit gingivitis, (vi) promote healing of sores or cuts in the mouth, (vii) reduce levels of acid producing bacteria, (viii) increase relative levels of arginonlytic bacteria, (ix) inhibit microbial biofilm formation in the oral cavity, (x) raise and/or maintain plaque pH levels of at least pH 5.5 following sugar challenge, (xi) reduce plaque accumulation, (xii) treat, relieve or reduce dry mouth, (xiii) clean the teeth and oral cavity, (xiv) reduce erosion, (xv) whiten teeth, (xvi) immunize the teeth against cariogenic bacteria; and or (xvii) promote systemic health, including cardiovascular health, e.g. by reducing potential for systemic infection via the oral tissues; comprising use of an instrument according to claim 1 by a person in need thereof.

14. The instrument of claim 1 , the composition further comprising a fluoride ion source.

15. The instrument of claim 14 , wherein said fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.

16. The instrument of claim 1 , the composition further comprising a potassium ion source.

17. The instrument of claim 16 , wherein said potassium ion source is selected from potassium nitrate and potassium chloride.

18. The instrument of claim 1 wherein the scaffold comprises a plastic.

19. The instrument of claim 1 wherein the scaffold comprises a material selected from polyethylene, polymethyl methacrylate, polyurethane, polyethylene terephthalate, polypropylene, polystyrene, polyamides, bioplastic, biodegradable plastics, and combinations thereof.

20. The instrument of claim 1 wherein the basic amino acid reversibly resides within said pores.

Assignees

• Prencipe Michael
• Robinson Richard Scott
• Kohli Rajnish
• Sullivan Richard J
• Cummins Diane
• Colgate Palmolive Co

Inventors

• Prencipe Michael
• Robinson Richard Scott
• Kohli Rajnish
• Sullivan Richard J
• Cummins Diane

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title