Obesity animal model and methods for making and using thereof
US-2015208620-A1 · Jul 30, 2015 · US
Obesity animal model and methods for making and using thereof
US10130080B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10130080-B2 |
| Application number | US-201314420410-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 1, 2013 |
| Priority date | Aug 8, 2012 |
| Publication date | Nov 20, 2018 |
| Grant date | Nov 20, 2018 |
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- Title
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Abstract
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The application provides, among others, methods for constructing animal obesity models, methods for screening microorganism or composition of microorganisms that may cause obesity, methods for screening therapeutic targets for treating metabolic disorders, and methods for screening or evaluating microorganisms, compounds, food, recipes, formulations, drugs, nutritional supplements, healthcare products, beverages and other items for preventing and treating metabolic diseases.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for establishing a non-human obesity animal model that develops obesity, the method comprising, inoculating a non-human germ-free animal with Enterobacter cloacea 29, and feeding the inoculated animal with a diet having at least 34.9% of fat content for a period of time to provide the non-human obesity animal model. 2. The method of claim 1 , wherein the non-human obesity animal model manifests a metabolic syndrome comprising at least one of obesity, insulin resistance, or chronic inflammation. 3. The method of claim 1 , wherein the non-human obesity animal model is a mouse, a rat, a rabbit, a monkey, a pig, or a Guinean pig. 4. The method of claim 1 , wherein the inoculating the non-human germ-free animal comprises inoculating the non-human germ-free animal by at least one of intragastric administration, topical administration, or oral administration. 5. The method of claim 1 , wherein the inoculating the non-human germ-free animal comprises inoculating the non-human germ-free animal with at least 10 2 bacteria cells.
Assignees
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Classifications
- A01K67/0271Primary
Chimeric vertebrates, e.g. comprising exogenous cells · CPC title
Animal models for infectious diseases · CPC title
Murine · CPC title
Animal model for inflammation · CPC title
Animals on a special diet · CPC title
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Frequently asked questions
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- What does patent US10130080B2 cover?
- The application provides, among others, methods for constructing animal obesity models, methods for screening microorganism or composition of microorganisms that may cause obesity, methods for screening therapeutic targets for treating metabolic disorders, and methods for screening or evaluating microorganisms, compounds, food, recipes, formulations, drugs, nutritional supplements, healthcare p…
- Who is the assignee on this patent?
- Univ Shanghai Jiaotong, Perfect China Co Ltd, Perfect China Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification A01K67/0271. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).