Macromonomer mixture, terminal-reactive polymer mixture, intermediate for macromonomer and silicone hydrogel

Patent metadata

Field	Value
Publication number	US-10125209-B2
Application number	US-201414264465-A
Country	US
Kind code	B2
Filing date	Apr 29, 2014
Priority date	Dec 28, 2009
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

To obtain a hydrophilic macromonomer mixture which is a highly polymerized hydrophilic macromonomer, has few components not bonded to the polymer chain after polymerization, and is less likely to leaching. Provided is a macromonomer mixture containing macromonomer A being a macromonomer having a group obtained by further introducing a polymerizable group into a reactive group derived from a polymerization initiator at an end thereof; and macromonomer B being a macromonomer having a group obtained by further introducing a polymerizable group into a reactive group derived from a chain transfer agent at an end thereof.

First claim

What is claimed is:

1. A macromonomer mixture comprising macromonomer A of Formula e4:

wherein R H is H or methyl; and wherein Formula e4 contains a polymeric group having n repeat units, wherein the polymeric group is derived from polymerization of a polymerizable monomer expressed by formula (m)

wherein R 1 through R 4 are any substituent groups on the polymerizable monomer;
and macromonomer B being a macromonomer having a group obtained by further introducing a polymerizable group into a reactive group on a chain transfer agent at an end thereof.

2. The macromonomer mixture of claim 1 wherein the reactive group is selected from the group consisting of a hydroxy group, an amino group, thiol, ester and carboxylic anhydride.

3. The macromonomer mixture of claim 1 , wherein the polymerizable monomer expressed by formula (m) is a hydrophilic monomer.

4. The macromonomer mixture of claim 3 , wherein the hydrophilic monomer is selected from the group consisting of N-vinylpyrrolidone, N,N-dimethylacrylamide, vinyl alcohol, (meth)acrylic acid, and 2-hydroxyethyl (meth)acrylate.

5. A method comprising polymerizing a hydrophilic monomer using a polymerization initiator having at least one functional group selected from the group consisting of a hydroxy group, an amino group and a carboxyl group in a molecule, and a chain transfer agent having at least one functional group selected from the group consisting of a hydroxy group, an amino group and a carboxyl group in a molecule to form the macromonomer mixture of any one of claim 1 , 2 or 4 , and reacting the macromonomer mixture with a compound having a radically polymerizable functional group.

6. The method of claim 5 , wherein the chain transfer agent is a chain transfer agent expressed by any one of the following general formulas (d1) to (d5):

wherein L 3 represents a divalent group having 1 to 10 carbon atoms; and R 10 and R 11 represent alkyl having 1 to 20 carbon atoms.

Assignees

• Johnson & Johnson Vision Care

Inventors

• Fujisawa Kazuhiko
• Nakamura Masataka

Classifications

• C08L43/04

  Homopolymers or copolymers of monomers containing silicon · CPC title

• C08F220/36

  containing oxygen in addition to the carboxy oxygen {, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate} · CPC title

• C08F220/38

  Esters containing sulfur · CPC title

• C08F290/046

  Polymers of unsaturated carboxylic acids or derivatives thereof · CPC title

• C08F290/02 Primary

  on to polymers modified by introduction of unsaturated end groups · CPC title