Derivatives of sobetirome
US-10870616-B2 · Dec 22, 2020 · US
US10125073B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10125073-B2 |
| Application number | US-201615556060-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 3, 2016 |
| Priority date | Mar 6, 2015 |
| Publication date | Nov 13, 2018 |
| Grant date | Nov 13, 2018 |
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Provided herein are 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol having a novel structure capable of being used to prevent or treat all diseases associated with NF-κB, IKK and STAT3, and a method of preparing the same.
Opening claim text (preview).
What is claimed is: 1. 2-Methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol represented by the following Formula 1: 2. A method of preparing 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol represented by Formula 1, which is prepared by allowing a compound of Formula 2 to react with a compound of Formula 3, as represented by the following Scheme 1: wherein X represents a halogen element. 3. The method of claim 2 , wherein the X is F, Cl, I, or Br. 4. The method of claim 2 , wherein the reaction is carried out in the presence of a palladium catalyst and a base. 5. The method of claim 2 , wherein the reaction is carried out by additionally adding a ligand comprising a phosphine or phosphite.
containing only methyl groups, e.g. cresols, xylenols · CPC title
by elimination of halogens, e.g. elimination of HCl · CPC title
by substitution of halogen · CPC title
by increasing the number of carbon atoms, e.g. by oligomerisation · CPC title
containing hydroxy or O-metal groups · CPC title
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