Dispensing device, storage device and method for dispensing a formulation

Patent metadata

Field	Value
Publication number	US-10124129-B2
Application number	US-80868608-A
Country	US
Kind code	B2
Filing date	Dec 24, 2008
Priority date	Jan 2, 2008
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

The invention relates to a dispensing device, a storage device and a method for dispensing a medical formulation. Multiple doses of the formulation are stored in a carrier having multiple storage members, each storage member containing a single dose. Each storage member comprises one duct or nozzle for dispensing the respective dose. The dispensing direction of the ducts or nozzles is directed in a lengthwise or indexing direction of the carrier. The storage device of the carrier is a peelable blister strip, wherein the ducts or nozzles can be opened one after the other by peeling the blister strip.

First claim

What is claimed is:

1. A dry powder inhaler ( 1 ) for dispensing a medical powder formulation ( 2 ) containing a drug, as a powder spray ( 3 ), wherein the medical powder formulation ( 2 ) contains a drug, and wherein the dry powder inhaler ( 1 ) comprises:
a storage device ( 4 ) including a carrier ( 5 ) having multiple storage members ( 6 ) in a flexible, band-like arrangement, wherein each of said multiple storage members ( 6 ) includes: (i) a respective storage cavity ( 9 ) containing a dose of the medical powder formulation ( 2 ), and (ii) a respective nozzle ( 11 ) having an outlet oriented such that the medical powder dose is dispensed from the respective storage cavity ( 9 ), through the respective nozzle, and outward from the outlet in a dispensing direction ( 12 ),
characterized in that the respective nozzle ( 11 ) includes a duct ( 10 ) that forms a channel from the storage cavity ( 9 ) to the outlet, where the duct ( 10 ) is formed integrally with the storage cavity ( 9 ), and the dispensing direction ( 12 ) of the respective nozzle ( 11 ) is directed at least in a lengthwise or indexing direction of the carrier ( 5 ).

2. The dry powder inhaler according to claim 1 , characterized in that the carrier ( 5 ) is a blister strip.

3. The dry powder inhaler according to claim 1 , characterized in that the carrier ( 5 ) comprises a base layer ( 7 ) and a peelable cover layer ( 8 ), wherein the multiple storage members ( 6 ) are inserted or held between these layers ( 7 , 8 ) before and/or during dispensing.

4. The dry powder inhaler according to claim 1 , characterized in that the multiple storage members ( 6 ) are parts made separately from the carrier ( 5 ).

5. The dry powder inhaler according to claim 1 , characterized in that the multiple storage members ( 6 ) are formed by the carrier ( 5 ), a base layer ( 7 ) and a cover layer ( 8 ) of the carrier ( 5 ).

6. The dry powder inhaler according to claim 1 , characterized in that each of the multiple storage members ( 6 ) is a molded element, a cartridge, a capsule or a container.

7. The dry powder inhaler according to claim 1 , characterized in that each of the multiple storage members ( 6 ) is rigid or flexible.

8. The dry powder inhaler according to claim 1 , characterized in that the dry powder inhaler ( 1 ) further comprises an opening, connecting and/or supply means ( 14 ), a piercing element ( 15 ) for opening or piercing the multiple storage members ( 6 ) individually and/or supplying pressurized gas to each of the multiple storage members ( 6 ) to dispense the dose from each of said multiple storage members ( 6 ).

9. The dry powder inhaler according to claim 1 , characterized in that the dry powder inhaler ( 1 ) further comprises a means for providing pressurized gas for dispensing the medical powder formulation ( 2 ), wherein the dry powder inhaler ( 1 ) comprises a manually operated air pump ( 13 ) as means for providing pressurized gas.

10. The dry powder inhaler according to claim 1 , characterized in that the dry powder inhaler ( 1 ) is designed such that the carrier ( 5 ) is capable of being moved or indexed stepwise from one of said multiple storage members ( 6 ) to the next one of said multiple storage members ( 6 ).

11. The dry powder inhaler according to claim 1 , characterized in that the multiple storage members ( 6 ) or nozzles ( 11 ) are sealed by one common sealing or cover layer ( 8 ).

12. The dry powder inhaler of claim 1 , wherein the storage device ( 4 ) or carrier ( 5 ) is a peelable blister strip, wherein the nozzle ( 11 ) is capable of being opened one after the other by peeling the blister strip.

13. The dry powder inhaler of claim 1 , wherein the carrier ( 5 ) carries the storage members ( 6 ) formed separately from the carrier ( 5 ) rigidly or in a unmovable manner and is adapted that each of the storage members ( 6 ) or the nozzle ( 11 ) is capable of being opened without movement of the storage members ( 6 ) or a base layer ( 7 ) thereof by opening or peeling a common sealing or cover layer ( 8 ).

14. The dry powder inhaler of claim 1 , further comprising a mouthpiece including a longitudinal body having an inlet end and an outlet end, the inlet end being in fluid communication with the outlet of the respective nozzle ( 11 ), and the outlet end for delivering the dose of the medical powder formulation ( 2 ) to a user, wherein the outlet of the nozzle ( 11 ), the inlet end of the longitudinal body, and the outlet end of the longitudinal body are oriented along the dispensing direction ( 12 ).

15. The dry powder inhaler of claim 1 , wherein the duct ( 10 ) is always open and remains open even prior to dispensing of the powder formulation.

16. A storage device ( 4 ) for a medical powder formulation ( 2 ) containing a drug, for a dry powder inhaler ( 1 ), the storage device ( 4 ) comprising:
a carrier ( 5 ) having multiple storage members ( 6 ) in a flexible, band-like arrangement, wherein each of said multiple storage members ( 6 ) includes: (i) a respective storage cavity ( 9 ) containing a dose of the medical powder formulation ( 2 ), and (ii) a respective nozzle ( 11 ) having an outlet oriented such that the respective medical powder formulation dose ( 2 ) is dispensed from the respective storage cavity ( 9 ), through the respective nozzle, and outward from the outlet in a dispensing direction ( 12 ),
characterized in that the respective nozzle ( 11 ) includes a duct ( 10 ) that forms a channel from the storage cavity ( 9 ) to the outlet, where the duct ( 10 ) is formed integrally with the storage cavity ( 9 ), and the dispensing direction ( 12 ) of the respective nozzle ( 11 ) is directed in a lengthwise direction of the carrier ( 5 ).

17. A method, comprising:
dispensing a medical powder formulation ( 2 ) containing a drug, as a dry powder spray ( 3 ) from a blister strip comprising multiple storage members ( 6 ), wherein each of said multiple storage members ( 6 ) includes (i) a respective storage cavity ( 9 ) containing a dose of the medical powder formulation ( 2 ), and (ii) a respective nozzle ( 11 ) having an outlet oriented such that the medical powder formulation dose ( 2 ) is dispensed from the respective storage cavity ( 9 ), through the respective nozzle, and outward from the outlet in a dispensing direction ( 12 ), wherein the respective nozzle ( 11 ) includes a duct ( 10 ) that forms a channel from the storage cavity ( 9 ) to the outlet, where the duct ( 10 ) is formed integrally with the storage cavity ( 9 ), and the dispensing direction ( 12 ) of the respective nozzle ( 11 ) is directed in a lengthwise direction of the carrier ( 5 ), and
peeling the blister strip to open each of the multiple storage members ( 6 ) and expose the respective nozzle ( 11 ), one after the other, so that the medical powder formulation dose ( 2 ) in each of said multiple storage members ( 6 ) is dispensed one after the other.

18. Method according to claim 17 , characterized in that each of the storage members ( 6 ) or nozzle ( 11 ) is sealed by one common sealing or cover layer ( 8 ), wherein the common sealing or cover layer ( 8 ) is peeled.

19. Method according to claim 17 , characterized in that the storage members ( 6 ) are individually connected to a supply of pressurized gas by piercing each of the respective storage members ( 6 ) by means of a piercing element ( 15 ).

Assignees

• Dunne Stephen T
• Moser Achim
• Boehringer Ingelheim Int

Inventors

• Dunne Stephen T
• Moser Achim

Classifications

• A61M15/0061

  using pre-packed dosages having an insert inside · CPC title

• A61M15/0045 Primary

  using multiple prepacked dosages on a same carrier, e.g. blisters · CPC title

• A61M15/0051

  the dosages being arranged on a tape, e.g. strips · CPC title

• A61M2205/07

  having air pumping means · CPC title

• A61M2205/071

  hand operated · CPC title