Embolic devices

Patent metadata

Field	Value
Publication number	US-10124090-B2
Application number	US-201514678525-A
Country	US
Kind code	B2
Filing date	Apr 3, 2015
Priority date	Apr 3, 2014
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.

First claim

We claim:

1. An implantable coil comprising:
a shapeable polymeric filament formed from a combination of precursors comprising a trimethylolpropane ethoxylate triacrylamide macromer; t-butyl acrylamide monomer and a hydroxyethyl methacrylate monomer; and a crosslinker; and comprising at least one visualization agent; and
an overcoil wrapped multiple times around at least a portion of the shapeable polymeric filament, the overcoil configured to create contact area spacing between the filament and a delivery catheter.

2. The implantable coil according to claim 1 , having reduced beam hardening artifacts when imaged using computed tomography.

3. The implantable coil according to claim 1 , wherein the at least one visualization agent is selected from metallic powders, gadolinium, superparamagnetic iron oxide particles, barium sulfate or a combination thereof.

4. The implantable coil according to claim 1 , wherein the polymeric filament has a diameter of less than about 0.03 inches.

5. The implantable coil according to claim 1 , wherein the polymeric filament is non-resorbable by body tissues.

6. The implantable coil according to claim 1 , wherein the polymeric filament is biodegradable.

7. The implantable coil according to claim 1 , wherein the trimethylolpropane ethoxylate triacrylamide macromer is trimethylolpropane ethoxylate triacrylamide having a molecular weight of 900 g/mol.

8. The implantable coil according to claim 1 , wherein the cross-linker is N,N′-methylenebisacrylamide.

9. An implantable coil including:
a hydrogel filament consisting essentially of about 27% w/w trimethylolpropane ethoxylate triacrylamide 900, about 6% w/w t-butyl acrylamide, about 2% hydroxyethyl methacrylate, about 0.5% w/w N,N-methylenebisacrylamide, about 64% barium sulfate, and about 0.5% 2,2′-azobisisobutyronitrile, and
an overcoil wrapped multiple times around at least a portion of the filament, the overcoil configured to create contact area spacing between the filament and a delivery catheter.

10. An implantable coil including:
a hydrogel filament consisting essentially of about 30% w/w trimethylolpropane ethoxylate triacrylamide 900, about 6% w/w t-butyl acrylamide, about 2% hydroxyethyl methacrylate, about 0.75% w/w N,N-methylenebisacrylamide, about 48% barium sulfate, and about 0.5% 2,2′-azobisisobutyronitrile, and
an overcoil wrapped multiple times around at least a portion of the filament, the overcoil configured to create contact area spacing between the filament and a delivery catheter.

11. The implantable coil according to claim 1 , wherein the overcoil is formed of a polymeric material or a metallic material.

12. The implantable coil according to claim 11 , wherein the polymeric material includes nylon, PEEK, PTFE, EPTFE, or a combination thereof, or wherein the metallic material includes stainless steel, nitinol, cobalt, chromium, tantalum, gold, platinum, barium, or a combination thereof.

Assignees

• Microvention Inc
• Terumo Corp

Inventors

• Constant Michael
• Keeley Edward Michael
• Garretson Joshua
• Cruise Gregory M
• Graczyk Wendy

Classifications

• A61L31/048 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title

• A61L31/18

  Materials at least partially X-ray or laser opaque · CPC title

• A61L2300/102

  Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• A61L31/145

  Hydrogels or hydrocolloids · CPC title