Non-nanoparticulate application forms of macrolides
US-2024180822-A1 · Jun 6, 2024 · US
US10123978B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10123978-B2 |
| Application number | US-201815865650-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 9, 2018 |
| Priority date | Jul 30, 2012 |
| Publication date | Nov 13, 2018 |
| Grant date | Nov 13, 2018 |
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A patch for a nail for treating dermatophytosis which includes a pressure-sensitive adhesive layer containing an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive contains a copolymer of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate and the N-vinylpyrrolidone is 70:30 to 90:10.
Opening claim text (preview).
The invention claimed is: 1. A patch for a nail for treating dermatophytosis which comprises a pressure sensitive adhesive layer comprising an acrylic-based pressure-sensitive adhesive and 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof, wherein the acrylic-based pressure sensitive adhesive consists of a copolymer consisting of 2-ethylhexyl acrylate and N-vinylpyrrolidone, and wherein a mass ratio of the 2-ethylhexyl acrylate to the N-vinylpyrrolidone is 70:30 to 90:10. 2. The patch for a nail according to claim 1 , wherein the 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof is contained in an amount of 5 to 30% by mass based on the total mass of the pressure sensitive adhesive layer. 3. The patch for a nail according to claim 1 , wherein the 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof is contained in an amount of 5 to 20% by mass based on the total mass of the pressure sensitive adhesive layer. 4. The patch for nail according to claim 1 , wherein 2-(3, 5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol or a salt thereof is contained in an amount of 5 to 15% by mass based on the total mass of the pressure sensitive adhesive layer. 5. The patch for a nail according to claim 1 , wherein the dermatophytosis is caused by tinea unguium. 6. The patch for a nail according to claim 1 , wherein the nail is a human nail. 7. The patch for a nail according to claim 1 , wherein the pressure-sensitive adhesive layer has a thickness of 20 to 200 μm. 8. A method for treating dermatophytosis in a patient in need thereof comprising applying the patch according to claim 1 to a nail of the patient. 9. The method according to claim 8 , wherein the nail is a human nail. 10. The method according to claim 8 , wherein the dermatophytosis is caused by tinea unguium.
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